Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25097484 | 0.88 | HDAC6 (0.35) | KDM4EHDAC6LMNANPC1RAB9A | |
| SCHEMBL13086734 | 0.77 | NPC1 (0.36) | KDM4ELMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26859104 | 0.76 | SMN1; SMN2 (0.53) | KDM4ELMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24869559 | 0.74 | NPC1 (0.39) | KDM4ELMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24967875 | 0.74 | NPC1 (0.34) | KDM4ELMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18611835 | 0.70 | BRAF (0.36) | KDM4ELMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12243808 | 0.66 | ESR1 (0.40) | KDM4ELMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25680997 | 0.66 | RAB9A (0.41) | KDM4EHDAC6LMNANPC1RAB9A | |
| SCHEMBL23571997 | 0.65 | LMNA (0.32) | KDM4ELMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13086441 | 0.64 | DGAT1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020041301-A1 | PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT FACTOR D MEDICAL DISORDERS | ACHILLION PHARMACEUTICALS, INC. (US) | 2020-02-27 | — | — | WO | disclosed |