Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.36 |
| ▸ | THRA | P10827 | 10/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.31 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31664927 | 0.87 | THRA (0.36) | THRBTHRANPBWR1MEN1USP2 | |
| SCHEMBL21749369 | 0.80 | THRA (0.38) | THRBTHRANPBWR1MEN1USP2 | |
| SCHEMBL21769493 | 0.80 | NPBWR1 (0.36) | THRBTHRANPBWR1SLC16A3SLC16A1 | |
| SCHEMBL21769494 | 0.78 | NPBWR1 (0.35) | THRBTHRANPBWR1SLC16A3SLC16A1 | |
| SCHEMBL28566363 | 0.76 | PTGDR2 (0.42) | THRBNPBWR1MEN1USP2KMT2A | |
| SCHEMBL21749370 | 0.75 | THRA (0.42) | THRBTHRANPBWR1MEN1USP2 | |
| SCHEMBL21749380 | 0.73 | NPBWR1 (0.47) | THRBTHRANPBWR1 | |
| SCHEMBL21769844 | 0.73 | THRA (0.45) | THRBTHRA | |
| SCHEMBL28566985 | 0.72 | NPBWR1 (0.43) | THRBTHRANPBWR1 | |
| SCHEMBL21749466 | 0.72 | NPBWR1 (0.38) | THRBTHRANPBWR1SLC16A3SLC16A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10800767-B2 | Thyroid hormone receptor beta agonist compounds | Terns, Inc. (US) | 2020-10-13 | — | — | US | disclosed |
| US-20200062742-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | Terns, Inc. | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062742-A1 | THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS | THRB, THRA, TSHR | THRB 1/4885THRA 2/4885NPBWR1 158/4885 |
| US-10800767-B2 | Thyroid hormone receptor beta agonist compounds | THRB, THRA, TSHR | THRB 1/4885THRA 2/4885NPBWR1 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.