SCHEMBL2177141

SCHEMBL2177141

O=C(O)CCCNc1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.64
MAPT P10636 1/20 0.64
FFAR1 O14842 3/20 0.53
ATM Q13315 2/20 0.53
CDC25A P30304 1/20 0.53
CDC25B P30305 1/20 0.53
HDAC3 O15379 2/20 0.50
HDAC1 Q13547 2/20 0.50
HDAC2 Q92769 2/20 0.50
NCOR2 Q9Y618 1/20 0.50
MAPK1 P28482 1/20 0.50
ADRA1A P35348 1/20 0.50
HDAC4 P56524 1/20 0.50
SLC6A3 Q01959 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
HDAC7 Q8WUI4 1/20 0.50
HDAC10 Q969S8 1/20 0.50
HDAC11 Q96DB2 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27609848 0.98 ALDH1A1 (0.61) ALDH1A1MAPTFFAR1ATMCDC25A
SCHEMBL27591545 0.98 ALDH1A1 (0.61) ALDH1A1MAPTFFAR1ATMCDC25A
SCHEMBL6130488 0.94 MAPT (0.61) ALDH1A1MAPTFFAR1CDC25ACDC25B
SCHEMBL27797433 0.93 MAPT (0.55) ALDH1A1MAPTFFAR1ATMCDC25A
SCHEMBL16691726 0.92 ALDH1A1 (0.59) ALDH1A1MAPTFFAR1CDC25ACDC25B
SCHEMBL859720 0.92 ALDH1A1 (0.59) ALDH1A1MAPTFFAR1CDC25ACDC25B
SCHEMBL19816482 0.92 ALDH1A1 (0.59) ALDH1A1MAPTFFAR1CDC25ACDC25B
SCHEMBL15068944 0.92 ALDH1A1 (0.59) ALDH1A1MAPTFFAR1CDC25ACDC25B
SCHEMBL19816825 0.92 ALDH1A1 (0.59) ALDH1A1MAPTFFAR1CDC25ACDC25B
SCHEMBL4624978 0.92 ALDH1A1 (0.59) ALDH1A1MAPTFFAR1CDC25ACDC25B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1884513-A1 PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME Japan Tobacco, Inc. (JP) 2008-02-06 EP claimed
EP-1814904-A2 ANTIBIOTIC DROSOCIN DERIVATIVES Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO (NL) 2007-08-08 EP claimed
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents JAPAN TOBACCO INC. (JP) 2007-02-08 US claimed
WO-2006052129-A2 ANTIBIOTIC DROSOCIN DERIVATIVES NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) 2006-05-18 WO claimed
EP-0966454-B1 DISUBSTITUTED BICYCLIC HETEROCYCLES, THEIR PRODUCTION AND USE AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA (DE) 2003-05-07 EP claimed
US-6294293-B1 Polymer electrical storage device KT HOLDINGS, LLC 2001-09-25 US claimed
US-4946844-A Optically active benzoquinolizine compounds, process for preparing same, and antibacterial preparation containing same as active ingredient TOKYO TANABE CO., LTD. (JP) 1990-08-07 US claimed
EP-0323189-A2 Optically active benzoquinolizine compounds, process for preparing same, and antibacterial preparation containing same as active ingredient TOKYO TANABE COMPANY LIMITED (JP) 1989-07-05 EP claimed
EP-0226584-A1 GAS SENSORS, AND METHODS OF MAKING AND USING THEM Cogent Limited (GB) 1987-07-01 EP claimed
WO-1986001599-A1 GAS SENSORS, AND METHODS OF MAKING AND USING THEM COGENT LIMITED (GB) 1986-03-13 WO claimed
US-12478594-B2 Methods of treatment of kidney injury associated with infection or trauma University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2025-11-25 US disclosed
US-11703758-B2 Photosensitive composition for EUV light, pattern forming method, and method for manufacturing electronic device FUJIFILM CORPORATION (JP) 2023-07-18 US disclosed
US-20220226266-A1 Methods of Treatment of Kidney Injury Associated with Infection or Trauma NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-07-21 US disclosed
CN-111699181-A FAP inhibitors 海德堡大学 2020-09-22 CN disclosed
US-20200207691-A1 Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from Acute Kidney Injury UNIVERSITY OF PITTSBURGH - OF T 2020-07-02 US disclosed
EP-0648758-A1 4-Arylamino-benzopyran and related compounds BRISTOL-MYERS SQUIBB COMPANY (US) 1995-04-19 EP disclosed
US-4946844-A Optically active benzoquinolizine compounds, process for preparing same, and antibacterial preparation containing same as active ingredient TOKYO TANABE CO., LTD. (JP) 1990-08-07 US disclosed
EP-0323189-A2 Optically active benzoquinolizine compounds, process for preparing same, and antibacterial preparation containing same as active ingredient TOKYO TANABE COMPANY LIMITED (JP) 1989-07-05 EP disclosed
EP-0226584-A1 GAS SENSORS, AND METHODS OF MAKING AND USING THEM Cogent Limited (GB) 1987-07-01 EP disclosed
WO-1986001599-A1 GAS SENSORS, AND METHODS OF MAKING AND USING THEM COGENT LIMITED (GB) 1986-03-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220226266-A1 Methods of Treatment of Kidney Injury Associated with Infection or Trauma MMP8, PLAU, KLKB1 ALDH1A1 2405/4885MAPT 3860/4885FFAR1 4418/4885
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents PYGL, GYS2, AGL ALDH1A1 1278/4885MAPT 4621/4885FFAR1 2007/4885
US-20200207691-A1 Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from Acute Kidney Injury HDAC1, HDAC9, HDAC11 ALDH1A1 351/4885MAPT 4107/4885FFAR1 2810/4885
US-12478594-B2 Methods of treatment of kidney injury associated with infection or trauma HDAC1, HDAC2, HDAC4 ALDH1A1 1054/4885MAPT 3903/4885FFAR1 3984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.