Sugi Predict

Sugi Predict / Compounds / SCHEMBL2177533

SCHEMBL2177533

SCHEMBL2177533

CC(C)[C@@H](C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)c4cccc(C(F)(F)F)c4F)cc3)cc2C1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.40
▸ TP53 P04637 1/20 0.40
▸ CBLB Q13191 1/20 0.40
▸ SDCBP O00560 3/20 0.39
▸ SDC2 P34741 3/20 0.39
▸ AVPR2 P30518 1/20 0.39
▸ AVPR1A P37288 1/20 0.39
▸ TEK Q02763 1/20 0.39
▸ THRB P10828 2/20 0.39
▸ PTPRC P08575 1/20 0.38
▸ PDE3B Q13370 1/20 0.38
▸ PDE3A Q14432 1/20 0.38
▸ AURKA O14965 2/20 0.38
▸ AURKB Q96GD4 1/20 0.38
▸ APOB P04114 1/20 0.36
▸ MTTP P55157 1/20 0.36
▸ S1PR1 P21453 1/20 0.36
▸ S1PR3 Q99500 1/20 0.36
▸ KCNK3 O14649 1/20 0.36
▸ KCNK9 Q9NPC2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2177537 1.00 LMNA (0.40) LMNATP53CBLBSDCBPSDC2
SCHEMBL2179993 0.92 PTPRC (0.46) LMNATP53SDCBPSDC2THRB
SCHEMBL2179986 0.92 PTPRC (0.46) LMNATP53SDCBPSDC2THRB
SCHEMBL2177338 0.88 ITGA4 (0.43) LMNATP53SDCBPSDC2THRB
SCHEMBL2177345 0.88 ITGA4 (0.43) LMNATP53SDCBPSDC2THRB
SCHEMBL13718795 0.88 SMO (0.44) LMNATP53SDCBPSDC2THRB
SCHEMBL2179776 0.87 LMNA (0.43) LMNATP53SDCBPSDC2THRB
SCHEMBL2179769 0.87 LMNA (0.43) LMNATP53SDCBPSDC2THRB
SCHEMBL2180186 0.84 ITGB3 (0.41) LMNATP53SDCBPSDC2THRB
SCHEMBL13719287 0.84 ITGB3 (0.41) LMNATP53SDCBPSDC2THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8748426-B2 Inhibitors of diacylglycerol acyl transferase Piramal Enterprises Limited (IN) 2014-06-10 — — US claimed
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Enterprises Limited (IN) 2012-11-15 — — US claimed
EP-2519500-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Healthcare Ltd. (IN) 2012-11-07 — — EP claimed
WO-2011080718-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-07-07 — — WO claimed
US-8748426-B2 Inhibitors of diacylglycerol acyl transferase Piramal Enterprises Limited (IN) 2014-06-10 — — US disclosed
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Enterprises Limited (IN) 2012-11-15 — — US disclosed
EP-2519500-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Healthcare Ltd. (IN) 2012-11-07 — — EP disclosed
WO-2011080718-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-07-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE DGAT1, DGAT2, LCAT LMNA 2193/4885TP53 2093/4885CBLB 4872/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.