Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.57 |
| ▸ | HPGD | P15428 | 11/20 | 0.57 |
| ▸ | MAPT | P10636 | 10/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.57 |
| ▸ | NPC1 | O15118 | 9/20 | 0.57 |
| ▸ | RAB9A | P51151 | 8/20 | 0.57 |
| ▸ | TP53 | P04637 | 7/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.57 |
| ▸ | POLB | P06746 | 6/20 | 0.57 |
| ▸ | GFER | P55789 | 4/20 | 0.57 |
| ▸ | TNKS | O95271 | 3/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 11/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.49 |
| ▸ | GAA | P10253 | 9/20 | 0.49 |
| ▸ | GLA | P06280 | 5/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27961299 | 0.85 | NPC1 (0.55) | ALDH1A1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6439292 | 0.83 | ALDH1A1 (0.60) | ALDH1A1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6325048 | 0.81 | ALDH1A1 (0.57) | ALDH1A1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6492052 | 0.81 | ALDH1A1 (0.59) | ALDH1A1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6494902 | 0.77 | SMN1; SMN2 (0.59) | ALDH1A1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL7458021 | 0.77 | SMN1; SMN2 (0.53) | ALDH1A1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL5924246 | 0.75 | TYMS (0.51) | ALDH1A1PARP1MEN1KMT2A | |
| SCHEMBL28241148 | 0.73 | ALDH1A1 (0.58) | ALDH1A1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL222131 | 0.73 | ALDH1A1 (1.00) | ALDH1A1HPGDMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6324494 | 0.72 | RHEB (0.69) | ALDH1A1HPGDMAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210395242-A1 | HETEROCYCLIC COMPOUNDS AS AHR MODULATORS | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2021-12-23 | — | — | US | disclosed |
| US-20210395242-A1 | HETEROCYCLIC COMPOUNDS AS AHR MODULATORS | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2021-12-23 | — | — | US | disclosed |
| EP-3843853-A1 | HETEROCYCLIC COMPOUNDS AS AHR MODULATORS | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020043880-A1 | HETEROCYCLIC COMPOUNDS AS AHR MODULATORS | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210395242-A1 | HETEROCYCLIC COMPOUNDS AS AHR MODULATORS | AHR, ARNT, AIPL1 | ALDH1A1 253/4885HPGD 112/4885MAPT 4469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.