SCHEMBL21776990

SCHEMBL21776990

CC1(C)CCC(C)(C)c2cc3c(cc21)CC(Br)C3O

nearest known ligand 0.31

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RARB P10826 2/20 0.31
RARG P13631 2/20 0.31
RARA P10276 1/20 0.31
PRKD3 O94806 1/20 0.31
PRKCG P05129 1/20 0.31
PRKCB P05771 1/20 0.31
PRKCA P17252 1/20 0.31
PRKCH P24723 1/20 0.31
PRKCI P41743 1/20 0.31
PRKCE Q02156 1/20 0.31
PRKCQ Q04759 1/20 0.31
PRKCZ Q05513 1/20 0.31
PRKCD Q05655 1/20 0.31
PRKD1 Q15139 1/20 0.31
RXRA P19793 2/20 0.31
RXRB P28702 1/20 0.30
RXRG P48443 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21776835 0.75
SCHEMBL30082461 0.73 MEN1 (0.31)
SCHEMBL30666589 0.73 MEN1 (0.31)
SCHEMBL6940567 0.73 MEN1 (0.31)
SCHEMBL6938404 0.72 RARB (0.37) RARBRARGRARAPRKD3PRKCG
SCHEMBL4320370 0.71
SCHEMBL1852140 0.70 TRPM5 (0.40)
SCHEMBL1180151 0.70 OPRM1 (0.47)
SCHEMBL22815741 0.69 HTR1A (0.36)
SCHEMBL30667077 0.69 HTR1A (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3844196-B1 SUBSTITUTED BIS-2-INDENYL METALLOCENE COMPOUNDS SABIC GLOBAL TECHNOLOGIES BV (NL) 2023-03-08 EP disclosed
US-11472895-B2 Substituted bis-2-indenyl metallocene compounds SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2022-10-18 US disclosed
EP-4028437-A1 COMPOUNDS FOR USE IN CATALYST COMPOSITIONS FOR THE PRODUCTION OF POLYOLEFINS SABIC Global Technologies, B.V. (NL) 2022-07-20 EP disclosed
CN-113286831-A Substituted bis 2-indenyl metallocene compounds SABIC环球技术有限责任公司 2021-08-20 CN disclosed
US-20210253749-A1 SUBSTITUTED BIS-2-INDENYL METALLOCENE COMPOUNDS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2021-08-19 US disclosed
EP-3844196-A1 SUBSTITUTED BIS-2-INDENYL METALLOCENE COMPOUNDS SABIC Global Technologies B.V. (NL) 2021-07-07 EP disclosed
WO-2021048030-A1 COMPOUNDS FOR USE IN CATALYST COMPOSITIONS FOR THE PRODUCTION OF POLYOLEFINS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2021-03-18 WO disclosed
WO-2020043815-A1 SUBSTITUTED BIS-2-INDENYL METALLOCENE COMPOUNDS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2020-03-05 WO disclosed