Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.49 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26677090 | 0.80 | SIRT6 (0.57) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL17992259 | 0.79 | MAOB (0.45) | MAPTL3MBTL1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL19429565 | 0.78 | SIRT6 (0.54) | SIRT6MAPTALDH1A1RAB9AKMT2A | |
| SCHEMBL20398731 | 0.74 | SIRT6 (0.59) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL13539179 | 0.73 | SIRT6 (0.57) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL3306506 | 0.73 | SIRT6 (0.57) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL14387783 | 0.73 | SIRT6 (0.57) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL17992227 | 0.72 | ALDH1A1 (0.51) | NFKB1MAPTALDH1A1L3MBTL1RAB9A | |
| SCHEMBL17987946 | 0.72 | APLNR (0.40) | NFKB1MAPTALDH1A1L3MBTL1RAB9A | |
| SCHEMBL509740 | 0.71 | SIRT6 (0.46) | SIRT6JUNNFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025022915-A1 | METHOD FOR PRODUCING 2-ETHYLSULFONYL-1-HETEROARYLETHANONE COMPOUND | 日本曹達株式会社 | 2025-01-30 | — | — | WO | disclosed |
| US-20210230137-A1 | PYRAZINE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2021-07-29 | — | — | US | disclosed |
| US-11001567-B2 | Pyrazine compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2021-05-11 | — | — | US | disclosed |
| US-20200109128-A1 | PYRAZINE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2020-04-09 | — | — | US | disclosed |
| US-10577343-B2 | Pyrazine compound and arthropod pest control agent containing same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2020-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230137-A1 | PYRAZINE COMPOUND | PPOX, NOX5, NISCH | SIRT6 1562/4885JUN 3593/4885NFKB1 2130/4885 |
| US-10577343-B2 | Pyrazine compound and arthropod pest control agent containing same | PPOX, NOX5, NISCH | SIRT6 1534/4885JUN 3705/4885NFKB1 2489/4885 |
| US-11001567-B2 | Pyrazine compound | PPOX, NOX5, NISCH | SIRT6 1562/4885JUN 3593/4885NFKB1 2130/4885 |
| US-20200109128-A1 | PYRAZINE COMPOUND | PPOX, NOX5, NISCH | SIRT6 1562/4885JUN 3593/4885NFKB1 2130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.