Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.47 |
| ▸ | ABL1 | P00519 | 8/20 | 0.47 |
| ▸ | EGFR | P00533 | 8/20 | 0.47 |
| ▸ | HCK | P08631 | 8/20 | 0.47 |
| ▸ | SRC | P12931 | 8/20 | 0.47 |
| ▸ | KDR | P35968 | 8/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.47 |
| ▸ | MTOR | P42345 | 8/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.47 |
| ▸ | PRKDC | P78527 | 8/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.47 |
| ▸ | CTSS | P25774 | 6/20 | 0.43 |
| ▸ | CTSK | P43235 | 4/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL217790 | 0.85 | ABL1 (0.49) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL16665685 | 0.83 | PIK3CD (0.67) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL19414369 | 0.78 | PIK3CD (0.64) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL19414293 | 0.77 | ALDH1A1 (0.50) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL20093454 | 0.77 | SRC (0.61) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL149180 | 0.76 | PIK3CD (0.55) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL19414398 | 0.75 | MAP4K4 (0.54) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL11306 | 0.75 | SRC (0.47) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL21575209 | 0.75 | BTK (0.53) | ABL1KDRCTSSCTSKRXRA | |
| SCHEMBL19414295 | 0.73 | SRC (0.47) | PIK3CDABL1EGFRHCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210401840-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2021-12-30 | — | — | US | disclosed |
| US-10322130-B2 | Substituted chromenones as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2019-06-18 | — | — | US | disclosed |
| US-20190105324-A9 | SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2019-04-11 | — | — | US | disclosed |
| US-10220035-B2 | Compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2019-03-05 | — | — | US | disclosed |
| US-20180110783-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2018-04-26 | — | — | US | disclosed |
| WO-2012151525-A9 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2012-12-13 | — | — | WO | disclosed |
| WO-2012151525-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2012-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210401840-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKCB | PIK3CD 47/4885ABL1 334/4885EGFR 1359/4885 |
| US-20190105324-A9 | SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKAR2B | PIK3CD 89/4885ABL1 464/4885EGFR 1502/4885 |
| US-10220035-B2 | Compounds as modulators of protein kinases | PRKCA, PRKCH, PRKCE | PIK3CD 30/4885ABL1 297/4885EGFR 1203/4885 |
| US-20180110783-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKCB | PIK3CD 47/4885ABL1 334/4885EGFR 1359/4885 |
| US-10322130-B2 | Substituted chromenones as modulators of protein kinases | MAP3K1, CSNK1A1, MAP3K2 | PIK3CD 148/4885ABL1 376/4885EGFR 807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.