Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN4A | P35499 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.33 |
| ▸ | GPR142 | Q7Z601 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | GIPR | P48546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14480505 | 0.81 | KCNH2 (0.42) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL14480820 | 0.81 | KCNH2 (0.63) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL14480861 | 0.77 | KCNH2 (0.65) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL21780434 | 0.77 | KCNH2 (0.46) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL13717427 | 0.68 | SCN5A (0.43) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL27957259 | 0.68 | PLAT (0.43) | GCGRGIPRALDH1A1HRH3 | |
| SCHEMBL13718288 | 0.67 | GPR139 (0.41) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL13718297 | 0.66 | DDR1 (0.43) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL14552606 | 0.66 | ROCK2 (0.45) | KCNH2SCN5ASCN1ASCN4ASCN9A | |
| SCHEMBL21780458 | 0.63 | GPR142 (0.37) | KCNH2SCN5ASCN1ASCN4ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101013-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |