Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.43 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21780420 | 0.86 | KMT2A (0.55) | LMNATSHRTACR3POLBMEN1 | |
| SCHEMBL21780440 | 0.83 | LMNA (0.48) | LMNATSHRTACR3POLBSLC6A9 | |
| SCHEMBL21780417 | 0.83 | KCNH2 (0.49) | CFTRLMNATSHRTACR3SLC6A9 | |
| SCHEMBL21780479 | 0.83 | LMNA (0.47) | LMNATSHRTACR3POLBSLC6A9 | |
| SCHEMBL21780441 | 0.82 | LMNA (0.47) | LMNATSHRTACR3POLBSLC6A9 | |
| SCHEMBL21780426 | 0.81 | KMT2A (0.53) | LMNATSHRPOLBMEN1KMT2A | |
| SCHEMBL21780432 | 0.78 | TLR9 (0.43) | LMNATSHRPOLBKMT2A | |
| SCHEMBL21780486 | 0.78 | PTGDR2 (0.47) | LMNATSHRTACR3MEN1KMT2A | |
| SCHEMBL21780489 | 0.77 | MCHR1 (0.52) | LMNATSHRKCNH2KMT2ASCN9A | |
| SCHEMBL15566425 | 0.77 | MEN1 (0.65) | GPR119MAPTTSHRHDAC4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101013-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |