Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TACR3 | P29371 | 1/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MGAM | O43451 | 2/20 | 0.41 |
| ▸ | SI | P14410 | 2/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21780503 | 0.93 | KCNK3 (0.43) | LMNATSHRKCNK3KCNK9PIK3CA | |
| SCHEMBL21780440 | 0.89 | LMNA (0.48) | LMNATSHRTACR3SLC6A9KCNK3 | |
| SCHEMBL21780479 | 0.88 | LMNA (0.47) | LMNATSHRTACR3SLC6A9KCNK3 | |
| SCHEMBL21780420 | 0.85 | KMT2A (0.55) | LMNATSHRTACR3SCN9AGAA | |
| SCHEMBL21780486 | 0.83 | PTGDR2 (0.47) | LMNATSHRTACR3KCNK3KCNK9 | |
| SCHEMBL21780417 | 0.82 | KCNH2 (0.49) | LMNATSHRTACR3SLC6A9KCNH2 | |
| SCHEMBL21780432 | 0.82 | TLR9 (0.43) | LMNATSHRKCNK3KCNK9GAA | |
| SCHEMBL21780474 | 0.82 | GPR119 (0.51) | LMNATSHRTACR3SLC6A9KCNH2 | |
| SCHEMBL21780426 | 0.78 | KMT2A (0.53) | LMNATSHRSCN9AGAAPOLB | |
| SCHEMBL21780489 | 0.77 | MCHR1 (0.52) | LMNATSHRKCNH2SCN9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101013-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |