Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TACR3 | P29371 | 1/20 | 0.46 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21780420 | 0.89 | KMT2A (0.55) | LMNATSHRTACR3SCN9AGAA | |
| SCHEMBL21780440 | 0.84 | LMNA (0.48) | KCNH2LMNATSHRTACR3SCN9A | |
| SCHEMBL21780479 | 0.83 | LMNA (0.47) | KCNH2LMNATSHRTACR3SCN7A | |
| SCHEMBL21780474 | 0.83 | GPR119 (0.51) | KCNH2LMNATSHRTACR3SCN9A | |
| SCHEMBL21780441 | 0.82 | LMNA (0.47) | KCNH2LMNATSHRTACR3SCN9A | |
| SCHEMBL21780426 | 0.81 | KMT2A (0.53) | LMNATSHRSCN9AGAAHPGD | |
| SCHEMBL21780489 | 0.80 | MCHR1 (0.52) | KCNH2LMNATSHRSCN9AGAA | |
| SCHEMBL21780486 | 0.78 | PTGDR2 (0.47) | LMNATSHRTACR3MEN1KMT2A | |
| SCHEMBL3992911 | 0.77 | CFD (0.51) | KDM1AHPGD | |
| SCHEMBL21780432 | 0.76 | TLR9 (0.43) | LMNATSHRGAAHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101013-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |