Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | GPR142 | Q7Z601 | 4/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | GLP1R | P43220 | 3/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22563248 | 0.81 | TLR8 (0.36) | ROCK2ROCK1GPR142PIK3CASIGMAR1 | |
| SCHEMBL21780467 | 0.80 | KCNH2 (0.45) | ROCK2ROCK1GPR142PIK3CASIGMAR1 | |
| SCHEMBL16986534 | 0.72 | SIGMAR1 (0.39) | ROCK2ROCK1DGAT1GPR142SIGMAR1 | |
| SCHEMBL22563269 | 0.72 | KCNH2 (0.45) | ROCK2ROCK1GPR142CA12CA9 | |
| SCHEMBL14481575 | 0.72 | CA9 (0.41) | ROCK2ROCK1DGAT1GPR142KDM2B | |
| SCHEMBL21780456 | 0.68 | KCNH2 (0.61) | ROCK2ROCK1GPR142CA12CA9 | |
| SCHEMBL23842773 | 0.67 | MEN1 (0.36) | PIK3CATRPV1KDM4ELMNAPOLB | |
| SCHEMBL21780458 | 0.62 | GPR142 (0.37) | ROCK2ROCK1GPR142PIK3CACA12 | |
| SCHEMBL14353998 | 0.61 | GPR142 (0.56) | ROCK2ROCK1GPR142PIK3CASIGMAR1 | |
| SCHEMBL16986527 | 0.61 | SIGMAR1 (0.45) | ROCK2ROCK1GPR142SIGMAR1TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |