Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31678688 | 0.68 | PTGS2 (0.50) | CYP17A1CYP19A1CYP11B1CYP11B2CFTR | |
| Styrene SCHEMBL4450343 | 0.68 | ALDH1A1 (0.48) | FGF23CYP19A1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL7212942 | 0.67 | ALDH1A1 (0.53) | FGF23CFTRGOPCALDH1A1PTGS2 | |
| Styrene SCHEMBL4360718 | 0.66 | ALDH1A1 (0.45) | FGF23ALDH1A1TSHR | |
| SCHEMBL28383000 | 0.63 | CFTR (0.44) | CFTRGOPCALDH1A1TSHRPTGS2 | |
| SCHEMBL5529589 | 0.63 | FGF23 (0.44) | FGF23CYP19A1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL24808048 | 0.62 | PTGS2 (0.49) | FGF23CFTRGOPCALDH1A1PTGS2 | |
| SCHEMBL20663060 | 0.60 | CFTR (0.37) | FGF23CYP17A1CYP19A1CYP11B1CYP11B2 | |
| Biphenyl SCHEMBL664141 | 0.60 | ALDH1A1 (0.60) | ALDH1A1TSHRPTGS2PTGS1 | |
| SCHEMBL2329784 | 0.59 | PTGS2 (0.50) | FGF23CFTRGOPCALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233828-B1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2020-03-04 | — | — | EP | disclosed |