Nevadensin

Nevadensin

SCHEMBL2178589

COc1ccc(-c2cc(=O)c3c(O)c(OC)c(O)c(OC)c3o2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.85
PPARG P37231 2/20 0.85
MAPK1 P28482 2/20 0.85
MEN1 O00255 2/20 0.71
KMT2A Q03164 2/20 0.71
CYP3A4 P08684 2/20 0.71
ABCB1 P08183 1/20 0.71
PKM P14618 1/20 0.71
ABCG2 Q9UNQ0 1/20 0.71
FLT3 P36888 2/20 0.67
MAPT P10636 2/20 0.67
NPC1 O15118 1/20 0.67
POLB P06746 1/20 0.67
KIT P10721 1/20 0.67
NFKB1 P19838 1/20 0.67
OPRD1 P41143 1/20 0.67
RAB9A P51151 1/20 0.67
NFKB2 Q00653 1/20 0.67
RELA Q04206 1/20 0.67
USP2 O75604 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nevadensin SCHEMBL29155335 1.00 ALDH1A1 (0.85) ALDH1A1PPARGMAPK1MEN1KMT2A
Gardenin B SCHEMBL1764516 0.92 ALDH1A1 (1.00) ALDH1A1PPARGMAPK1MEN1KMT2A
SCHEMBL31237871 0.92 ALDH1A1 (0.81) ALDH1A1PPARGMAPK1MEN1KMT2A
SCHEMBL30683238 0.91 PPARG (0.85) ALDH1A1PPARGMAPK1MEN1KMT2A
SCHEMBL2180082 0.91 PPARG (0.85) ALDH1A1PPARGMAPK1MEN1KMT2A
SCHEMBL29449516 0.91 ALDH1A1 (0.88) ALDH1A1PPARGMAPK1MEN1KMT2A
SCHEMBL4626785 0.88 ALDH1A1 (0.72) ALDH1A1PPARGMAPK1CYP3A4PKM
SCHEMBL1250942 0.87 ALDH1A1 (0.73) ALDH1A1PPARGMAPK1MEN1KMT2A
SCHEMBL1764664 0.85 ALDH1A1 (0.86) ALDH1A1PPARGMAPK1MEN1KMT2A
Sudachitin SCHEMBL6361479 0.84 ALDH1A1 (0.84) ALDH1A1MAPK1MEN1KMT2ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 238 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12605323-B2 Composition for inhibiting hair graying, and use thereof LG HOUSEHOLD & HEALTH CARE LTD. (KR) 2026-04-21 US claimed
EP-4698662-A2 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2026-02-25 EP claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
WO-2024220449-A9 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2025-04-03 WO claimed
US-20250011393-A1 FLAVONOID-COLLAGEN CROSSLINKED ANTIOXIDANT HYDROGEL NORTH CAROLINA STATE UNIVERSITY 2025-01-09 US claimed
WO-2024258363-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES SAHIN FIKRET (TR) 2024-12-19 WO claimed
WO-2024220449-A2 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES ASKLEPIOS BIOPHARMACEUTICAL, INC. (US) 2024-10-24 WO claimed
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 US claimed
US-20240099344-A1 HYDROXY- AND METHOXY-SUBSTITUTED FLAVONOIDS AND THEIR USE FIRMENICH SA (CH) 2024-03-28 US claimed
US-20230330120-A1 COMPOSITION FOR PREVENTING HAIR LOSS OR PROMOTING HAIR REGROWTH LG HOUSEHOLD & HEALTH CARE LTD. (KR) 2023-10-19 US claimed
CN-104869848-A Increasing the bioavailability of flavan-3-ols by polyphenols NESTEC SA 2015-08-26 CN claimed
CN-104502479-A Quality detection method of preparation for treating tracheitis and bronchitis GUIZHOU PROVINCE KEHUI PHARMACEUTICAL FACTORY 2015-04-08 CN claimed
WO-2014083172-A1 INCREASING THE BIOAVAILABILITY OF FLAVAN-3-OLS BY POLYPHENOLS NESTEC S.A. (CH) 2014-06-05 WO claimed
CN-101723768-B Method for carrying out hydroxyethylation on phenolic acid compounds and products thereof KEY LAB OF CHEMISTRY FOR NATURAL PRODUCTS OF GUIZHOU PROVINCE AND CHINESE ACADEMY OF SCIENCES 2013-12-25 CN claimed
CN-103472143-A Cold-curing preparation and detection method for intermediate product GUIZHOU BAILING GROUP PHARMACEUTICAL CO LTD 2013-12-25 CN claimed
US-20120315332-A1 PHARMACEUTICAL COMPOSITION INCLUDING SUNFLOWER EXTRACT, PREPARATIVE METHOD AND USE THEREOF PEIXUE LING (CN) 2012-12-13 US claimed
EP-2520305-A1 MEDICINAL COMPOSITION INCLUDING SUNFLOWER EXTRACT, PREPARATIVE METHOD AND USE THEREOF Ling, Peixue (CN) 2012-11-07 EP claimed
CN-102018740-B Pharmaceutical composition containing sunflower leaf extract and use thereof PEIXUE LING 2012-05-23 CN claimed
CN-102018740-A Medicinal composition containing extracts of leaves of helianthus and application of the same PEIXUE LING 2011-04-20 CN claimed
CN-101723768-A Method for carrying out hydroxyethylation on phenolic acid compounds and products thereof KEY LAB OF CHEMISTRY FOR NATUR 2010-06-09 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120315332-A1 PHARMACEUTICAL COMPOSITION INCLUDING SUNFLOWER EXTRACT, PREPARATIVE METHOD AND USE THEREOF HMGCR, LSS, CYP8B1 ALDH1A1 1355/4885PPARG 513/4885MAPK1 3631/4885
US-12605323-B2 Composition for inhibiting hair graying, and use thereof CTNND1, CTNNB1, GSK3B ALDH1A1 3922/4885PPARG 4247/4885MAPK1 1537/4885
US-20230330120-A1 COMPOSITION FOR PREVENTING HAIR LOSS OR PROMOTING HAIR REGROWTH WNT1, WNT3A, WNT3 ALDH1A1 1463/4885PPARG 1159/4885MAPK1 1987/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.