Gardenin B

Gardenin B

SCHEMBL1764516

COc1ccc(-c2cc(=O)c3c(O)c(OC)c(OC)c(OC)c3o2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 1.00
PPARG P37231 2/20 1.00
MAPK1 P28482 2/20 1.00
CYP3A4 P08684 3/20 0.80
MEN1 O00255 3/20 0.80
KMT2A Q03164 3/20 0.80
ABCB1 P08183 1/20 0.80
PKM P14618 1/20 0.80
ABCG2 Q9UNQ0 1/20 0.80
MAPT P10636 3/20 0.73
USP2 O75604 1/20 0.73
LMNA P02545 1/20 0.73
ELANE P08246 1/20 0.73
FLT3 P36888 2/20 0.67
POLB P06746 2/20 0.67
NPC1 O15118 1/20 0.67
KIT P10721 1/20 0.67
NFKB1 P19838 1/20 0.67
OPRD1 P41143 1/20 0.67
RAB9A P51151 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29449516 0.93 ALDH1A1 (0.88) ALDH1A1PPARGMAPK1CYP3A4MEN1
Nevadensin SCHEMBL2178589 0.92 ALDH1A1 (0.85) ALDH1A1PPARGMAPK1CYP3A4MEN1
Nevadensin SCHEMBL29155335 0.92 ALDH1A1 (0.85) ALDH1A1PPARGMAPK1CYP3A4MEN1
Xanthomicrol SCHEMBL6257160 0.91 PPARG (1.00) ALDH1A1PPARGMAPK1CYP3A4MEN1
SCHEMBL31237871 0.90 ALDH1A1 (0.81) ALDH1A1PPARGMAPK1CYP3A4MEN1
Tangeretin SCHEMBL23629519 0.89 ALDH1A1 (1.00) ALDH1A1PPARGMAPK1CYP3A4MEN1
Tangeretin SCHEMBL19740 0.89 ALDH1A1 (1.00) ALDH1A1PPARGMAPK1CYP3A4MEN1
Tangeretin SCHEMBL29549538 0.89 ALDH1A1 (1.00) ALDH1A1PPARGMAPK1CYP3A4MEN1
SCHEMBL26112503 0.88 PPARG (0.81) ALDH1A1PPARGMAPK1CYP3A4MEN1
Sideritiflavone SCHEMBL29973995 0.86 PPARG (0.77) ALDH1A1PPARGMAPK1CYP3A4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 164 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115294-A1 DERIVATIVES OF 5-HYDROXYLATED POLYMETHOXYFLAVONES WITH ENHANCED BIOAVAILABILITY FOR ORAL DELIVERY AND COMPOSITIONS THEREOF DEEPSENSE BIOTECHNOLOGIES INC (US) 2026-04-30 US claimed
CN-120009445-A Detection method and kit for ageing process 中国检验检疫科学研究院 2025-05-16 CN claimed
US-20250051551-A1 IMPROVED POLYMER COMPOSITES WARNER BABCOCK INSTITUTE FOR GREEN CHEMISTRY, LLC (US) 2025-02-13 US claimed
CN-119074820-A Polymethoxy flavone component enriched from pericarpium citri reticulatae, and enrichment method and application thereof 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) 2024-12-06 CN claimed
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 US claimed
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2023-03-23 US claimed
WO-2022182523-A1 COMPOSITIONS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
WO-2022182527-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
CN-114146124-A Application of phyllanthus emblica embryo polymethoxylated flavonoids compound in preparation of antioxidant 中山大学 2022-03-08 CN claimed
CN-114053346-A Application of phyllanthus emblica embryo polymethoxylated flavonoids compound in preparation of blood fat reducing product 中山大学 2022-02-18 CN claimed
WO-2007024982-A2 METHODS FOR MANAGING ADIPOCYTE FAT ACCUMULATION WELLGEN, INC. (US) 2007-03-01 WO claimed
US-20070042972-A1 Compositions and methods for optimizing exercise recovery RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2007-02-22 US claimed
WO-2006127996-A2 COMPOSITIONS AND METHODS FOR OPTIMIZING EXERCISE RECOVERY RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2006-11-30 WO claimed
US-20040152760-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases PROTAMED, INC. 2004-08-05 US claimed
JP-2003532634-A 2003-11-05 JP claimed
EP-1244435-A2 POLYHYDROXYLATED AROMATIC COMPOUNDS FOR THE TREATMENT OF AMYLOIDOSIS AND $g(a)-SYNUCLEIN FIBRIL DISEASES Proteotech Inc. (US) 2002-10-02 EP claimed
US-20010047032-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases PROTAMED, INC. 2001-11-29 US claimed
WO-2001049281-A2 POLYHYDROXYLATED AROMATIC COMPOUNDS FOR THE TREATMENT OF AMYLOIDOSIS AND α-SYNUCLEIN FIBRIL DISEASES PROTEOTECH, INC. (US) 2001-07-12 WO claimed
EP-0605261-B1 Use of a flavone derivative as taste modifier and a method of modifying taste SAN EI GEN FFI INC (JP) 1999-09-15 EP claimed
EP-0605261-A2 A taste modifier and a method of modifying taste SAN-EI GEN F.F.I., INC. (JP) 1994-07-06 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070042972-A1 Compositions and methods for optimizing exercise recovery GYS1, PYGM, PRDX5 ALDH1A1 3163/4885PPARG 178/4885MAPK1 1794/4885
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES FABP2, FABP4, GUSB ALDH1A1 2722/4885PPARG 319/4885MAPK1 3646/4885
US-20010047032-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases SNCA, PARK7, HTT ALDH1A1 1370/4885PPARG 391/4885MAPK1 2917/4885
US-20260115294-A1 DERIVATIVES OF 5-HYDROXYLATED POLYMETHOXYFLAVONES WITH ENHANCED BIOAVAILABILITY FOR ORAL DELIVERY AND COMPOSITIONS THEREOF PLIN3, PNLIP, FABP2 ALDH1A1 2873/4885PPARG 210/4885MAPK1 2886/4885
US-20040152760-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases SNCA, PARK7, HTT ALDH1A1 1370/4885PPARG 391/4885MAPK1 2917/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.