Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19662501 | 0.94 | HDAC1 (0.49) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL21787243 | 0.90 | MAPK1 (0.50) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL21787242 | 0.82 | SMYD3 (0.49) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL21786983 | 0.81 | HDAC6 (0.44) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL19662620 | 0.80 | GRIN1 (0.47) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL21787245 | 0.80 | HDAC1 (0.39) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL11092370 | 0.73 | HPGD (0.62) | HDAC6POLBHPGDHTTKDM4E | |
| SCHEMBL12553794 | 0.72 | HPGD (0.57) | HDAC6POLBHPGDHTTKDM4E | |
| SCHEMBL11089138 | 0.71 | POLB (0.56) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL11089847 | 0.70 | CDK1 (0.56) | HDAC6POLBHPGDHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230028321-A1 | NUCLEOTIDE DERIVATIVES AND METHODS OF USE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-01-26 | — | — | US | disclosed |
| US-20200069717-A1 | NUCLEOTIDE DERIVATIVES AND METHODS OF USE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200069717-A1 | NUCLEOTIDE DERIVATIVES AND METHODS OF USE THEREOF | POLRMT, NSUN2, RNGTT | HDAC1 4732/4885HDAC2 4794/4885HDAC3 4156/4885 |
| US-20230028321-A1 | NUCLEOTIDE DERIVATIVES AND METHODS OF USE THEREOF | POLRMT, NSUN2, NUDT1 | HDAC1 4822/4885HDAC2 4855/4885HDAC3 4397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.