SCHEMBL2178756

SCHEMBL2178756

N#Cc1[c]ncc(C#N)c1

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.35
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
GAA P10253 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2180063 0.77
SCHEMBL1026034 0.76
SCHEMBL1035312 0.76
SCHEMBL20554164 0.76
SCHEMBL1515421 0.76
SCHEMBL1026277 0.76
SCHEMBL2176290 0.76
SCHEMBL20554474 0.76
SCHEMBL20554241 0.76
SCHEMBL20554220 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4023640-A1 PHENYLIMIDAZOLE COMPOUND Otsuka Pharmaceutical Factory, Inc. (JP) 2022-07-06 EP disclosed
CN-113200962-A Phenylimidazole compounds 株式会社大塚制药工场 2021-08-03 CN disclosed
CN-108430977-B Phenylimidazole compounds 株式会社大塚制药工场 2021-06-08 CN disclosed
US-10570117-B2 Phenylimidazole compound OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 2020-02-25 US disclosed
US-20180354930-A1 PHENYLIMIDAZOLE COMPOUND OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) 2018-12-13 US disclosed
EP-3401310-A1 PHENYLIMIDAZOLE COMPOUND Otsuka Pharmaceutical Factory, Inc. (JP) 2018-11-14 EP disclosed
US-20110166162-A1 1,2-Benzisothiazole Compounds Useful for Combating Animal Pests BASF SE (DE) 2011-07-07 US disclosed
EP-1037106-B1 Color diffusion transfer photographic material FUJI PHOTO FILM CO LTD (JP) 2005-01-26 EP disclosed
EP-0772087-B1 Pyrazolylazophenol dye FUJI PHOTO FILM CO LTD (JP) 2004-09-08 EP disclosed
US-6495304-B2 NOVEL COLOR-DEVELOPING AGENT OF A 1,2,4- THIADIAZOL-5-YL HYDRAZINE TYPE FUJI PHOTO FILM CO., LTD. (JP) 2002-12-17 US disclosed
US-4916047-A POLYMERIC COMPOUND RELEASING USEFUL GROUP BY REDOX PROCESS TRIGGERED BY REDUCING AGENT FUJI PHOTO FILM CO., LTD. (JP) 1990-04-10 US disclosed
US-4886736-A COUPLERS AND COMPOUND CAPABLE OF RELEASING PHOTOGRAPHICALLY USEFUL GROUP UPON REDUCTION FUJI PHOTO FILM CO., LTD. (JP) 1989-12-12 US disclosed
US-4877720-A PHOTOGRAPHIC POLYMER WHICH UNDERGOES REDUCTION UPON DEVELOPMENT FUJI PHOTO FILM CO., LTD. (JP) 1989-10-31 US disclosed
EP-0334362-A2 Heat developable color light-sensitive material Fuji Photo Film Co., Ltd. (JP) 1989-09-27 EP disclosed
US-4840887-A USEFUL GROUP RELEASED BY CLEAVAGE BETWEEN SULFONYL GROUP AND A NITROGEN, SULFUR OR OXYGEN ATOM; STABILITY FUJI PHOTO FILM CO., LTD. (JP) 1989-06-20 US disclosed
US-4820622-A RELEASING DIFFUSIBLE DYE IN ALKALINE SYSTEM AFTER HALIDE REDUCTION FUJI PHOTO FILM CO., LTD. (JP) 1989-04-11 US disclosed
EP-0306833-A2 Silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1989-03-15 EP disclosed
US-4783396-A Silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1988-11-08 US disclosed
EP-0280252-A2 Silver halide photographic material and method for forming super high contrast image therewith FUJI PHOTO FILM CO., LTD. (JP) 1988-08-31 EP disclosed
EP-0220746-A2 Silver halide photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1987-05-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10570117-B2 Phenylimidazole compound LPL, PNLIP, LIPC HTT 4036/4885KDM4E 2007/4885ALDH1A1 263/4885
US-20110166162-A1 1,2-Benzisothiazole Compounds Useful for Combating Animal Pests GLRX3, CBR3, PRDX1 HTT 808/4885KDM4E 4261/4885ALDH1A1 2095/4885
US-20180354930-A1 PHENYLIMIDAZOLE COMPOUND PNLIP, PLIN1, HDAC11 HTT 1141/4885KDM4E 919/4885ALDH1A1 457/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.