Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.39 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21865601 | 0.73 | P2RX7 (0.42) | CYP3A4MAPTMAPK1P2RX7KCNH2 | |
| SCHEMBL4481286 | 0.71 | CCR2 (0.47) | CYP3A4MAPTMAPK1P2RX7TEAD1 | |
| SCHEMBL21789150 | 0.71 | ITGB3 (0.45) | CYP3A4MAPTMAPK1P2RX7KCNH2 | |
| SCHEMBL4495364 | 0.71 | CCR2 (0.47) | CYP3A4MAPTMAPK1P2RX7TEAD1 | |
| SCHEMBL21865730 | 0.71 | ITGB3 (0.45) | CYP3A4MAPTMAPK1P2RX7KCNH2 | |
| SCHEMBL26154086 | 0.70 | ALDH1A1 (0.65) | MAPTP2RX7KCNH2HRH3ALDH1A1 | |
| SCHEMBL21777493 | 0.68 | TPSAB1 (0.50) | P2RX7KCNH2HRH3TEAD1LSS | |
| SCHEMBL16839732 | 0.67 | OPRL1 (0.41) | LSSMAPK14FFAR1MTORPPARA | |
| SCHEMBL16839734 | 0.67 | OPRL1 (0.41) | LSSMAPK14FFAR1MTORPPARA | |
| SCHEMBL19650799 | 0.67 | BCHE (0.61) | HRH3TEAD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047447-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |