Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CD81 | P60033 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15362631 | 1.00 | GABRR1 (0.39) | GABRR1SLC1A2SLC1A1SLC6A4APLNR | |
| Hydrochloric Acid SCHEMBL16669413 | 0.98 | SLC1A2 (0.37) | GABRR1SLC1A2SLC1A1SLC6A4APLNR | |
| Trifluoroacetic Acid SCHEMBL965196 | 0.88 | SLC1A2 (0.35) | GABRR1SLC1A2SLC1A1SLC6A4 | |
| SCHEMBL16822029 | 0.81 | GAA (0.31) | — | |
| SCHEMBL12914984 | 0.81 | CD81 (0.32) | CD81 | |
| SCHEMBL12914987 | 0.81 | CD81 (0.32) | CD81 | |
| SCHEMBL6121809 | 0.79 | APLNR (0.42) | GABRR1SLC1A2SLC1A1SLC6A4APLNR | |
| SCHEMBL15352277 | 0.79 | APLNR (0.42) | GABRR1SLC1A2SLC1A1SLC6A4APLNR | |
| SCHEMBL21800873 | 0.79 | APLNR (0.42) | GABRR1SLC1A2SLC1A1SLC6A4APLNR | |
| SCHEMBL6382497 | 0.79 | APLNR (0.42) | GABRR1SLC1A2SLC1A1SLC6A4APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017506-B2 | ATX modulating agents | BIOGEN MA INC. (US) | 2018-07-10 | — | — | US | disclosed |
| EP-2877185-B1 | 2-(1-(1-(6-((CYCLOHEXYL)OXY)-5-(TRIFLUOROMETHYL)NAPHTHALEN-2-YL)ETHYL)PIPERIDIN-3-YL)ACETIC ACID DERIVATIVES AS AUTOTAXIN (ATX) MODULATORS FOR THE TREATMENT OF INFLAMMATIONS AND AUTOIMMUNE DISORDERS | BIOGEN MA INC (US) | 2018-05-23 | — | — | EP | disclosed |
| EP-2877166-B1 | 1-[7-(cis-4-methyl-cyclohexyloxy)-8-trifluoromethyl-naphthalen-2-ylmethyl]-piperidine-4-carboxylic acid derivatives as autotaxin (ATX) modulators for treating inflammations and autoimmune disorders | BIOGEN MA INC (US) | 2018-02-28 | — | — | EP | disclosed |
| US-20170158687-A1 | ATX MODULATING AGENTS | BIOGEN MA INC. | 2017-06-08 | — | — | US | disclosed |
| US-9555050-B2 | ATX modulating agents | BIOGEN MA INC. (US) | 2017-01-31 | — | — | US | disclosed |
| US-9522889-B2 | ATX modulating agents | BIOGEN MA INC. (US) | 2016-12-20 | — | — | US | disclosed |
| US-20160039825-A1 | S1P AND/OR ATX MODULATING AGENTS | BIOGEN MA INC. | 2016-02-11 | — | — | US | disclosed |
| EP-2970302-A1 | S1P AND/OR ATX MODULATING AGENTS | Biogen MA Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20150246063-A1 | ATX MODULATING AGENTS | BIOGEN IDEC MA INC. (US) | 2015-09-03 | — | — | US | disclosed |
| US-20150210647-A1 | ATX MODULATING AGENTS | BIOGEN MA, INC. | 2015-07-30 | — | — | US | disclosed |
| EP-2877185-A1 | ATX MODULATING AGENTS | Biogen Idec MA Inc. (US) | 2015-06-03 | — | — | EP | disclosed |
| EP-2877166-A1 | ATX MODULATING AGENTS | Biogen Idec MA Inc. (US) | 2015-06-03 | — | — | EP | disclosed |
| WO-2014152725-A1 | S1P AND/OR ATX MODULATING AGENTS | BIOGEN IDEC MA INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014018887-A1 | ATX MODULATING AGENTS | BIOGEN IDEC MA INC. (US) | 2014-01-30 | — | — | WO | disclosed |
| WO-2014018881-A1 | ATX MODULATING AGENTS | BIOGEN IDEC MA INC. (US) | 2014-01-30 | — | — | WO | disclosed |
| WO-2011080562-A1 | NOVEL AZA-PEPTIDES CONTAINING 2,2-DISUBSTITUTED CYCLOBUTYL AND/OR SUBSTITUTED ALKOXY BENZYL DERIVATIVES AS ANTIVIRALS | HETERO RESEARCH FOUNDATION (IN) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039825-A1 | S1P AND/OR ATX MODULATING AGENTS | ENPP2, S1PR1, S1PR2 | GABRR1 718/4885SLC1A2 3687/4885SLC1A1 3494/4885 |
| US-20150246063-A1 | ATX MODULATING AGENTS | ENPP2, ATXN10, ATXN2 | GABRR1 427/4885SLC1A2 433/4885SLC1A1 620/4885 |
| US-20150210647-A1 | ATX MODULATING AGENTS | ENPP2, ATXN10, ATXN2 | GABRR1 3414/4885SLC1A2 2321/4885SLC1A1 2290/4885 |
| US-20170158687-A1 | ATX MODULATING AGENTS | ENPP2, ATXN10, ATXN2 | GABRR1 3414/4885SLC1A2 2321/4885SLC1A1 2290/4885 |
| US-10017506-B2 | ATX modulating agents | ENPP2, ATXN10, ATXN2 | GABRR1 3414/4885SLC1A2 2321/4885SLC1A1 2290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.