Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.40 |
| ▸ | TNF | P01375 | 2/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19205749 | 1.00 | RIPK1 (0.40) | RIPK1TNFSCN1ASCN5ASCN8A | |
| SCHEMBL21796351 | 0.88 | TRPV1 (0.40) | RIPK1MEN1KMT2ARETRORC | |
| SCHEMBL19205763 | 0.88 | TRPV1 (0.40) | RIPK1MEN1KMT2ARETRORC | |
| SCHEMBL22261805 | 0.85 | RORC (0.42) | RIPK1NTRK1RORCTP53 | |
| SCHEMBL19205583 | 0.85 | RORC (0.42) | RIPK1NTRK1RORCTP53 | |
| SCHEMBL19205594 | 0.79 | KCNJ5 (0.42) | MEN1KMT2ARETNTRK1RORC | |
| SCHEMBL19205595 | 0.79 | KCNJ5 (0.42) | MEN1KMT2ARETNTRK1RORC | |
| SCHEMBL21796353 | 0.75 | NPC1 (0.42) | MEN1KMT2ACA1CA2CA12 | |
| SCHEMBL19205657 | 0.75 | NPC1 (0.42) | MEN1KMT2ACA1CA2CA12 | |
| SCHEMBL21796354 | 0.75 | SMN1; SMN2 (0.40) | MEN1KMT2ARETRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3331863-B1 | NOVEL COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2020-03-11 | — | — | EP | claimed |
| EP-3686187-A1 | PROCESS FOR THE PREPARATION OF ROR GAMMA MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2020-07-29 | — | — | EP | disclosed |