Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21796992 | 0.89 | GRM1 (0.40) | — | |
| SCHEMBL21796522 | 0.83 | LRRK2 (0.43) | LRRK2PDE3BPDE3A | |
| SCHEMBL21796920 | 0.80 | PIM1 (0.42) | LRRK2PDE3BPDE3A | |
| SCHEMBL21796588 | 0.78 | LRRK2 (0.37) | LRRK2PDE3BPDE3A | |
| SCHEMBL28619667 | 0.78 | LRRK2 (0.46) | LRRK2SPR | |
| SCHEMBL29043554 | 0.70 | NR3C1 (0.43) | — | |
| SCHEMBL23478560 | 0.70 | RXRA (0.44) | — | |
| SCHEMBL28750127 | 0.68 | ALDH1A1 (0.43) | — | |
| SCHEMBL21796921 | 0.68 | JAK2 (0.31) | — | |
| SCHEMBL22753188 | 0.66 | PDE3B (0.36) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137510-B | Compound (I) | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-07-20 | — | — | CN | disclosed |
| US-10975081-B2 | Substituted fused pyrazole compounds and their use as LRRK2 inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-04-13 | — | — | US | disclosed |
| US-20200079777-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975081-B2 | Substituted fused pyrazole compounds and their use as LRRK2 inhibitors | LRRK2, PARK7, PINK1 | LRRK2 1/4885SPR 1734/4885PDE3B 1423/4885 |
| US-20200079777-A1 | COMPOUNDS | LRRK2, PARK7, PINK1 | LRRK2 1/4885SPR 2723/4885PDE3B 3040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.