Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | EDNRB | P24530 | 2/20 | 0.50 |
| ▸ | EDNRA | P25101 | 2/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177837 | 0.81 | CYP2C19 (0.68) | MAPTLMNAALDH1A1SMN1; SMN2EDNRA | |
| SCHEMBL3434693 | 0.81 | KDM4E (0.58) | CYTH2LMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2180234 | 0.79 | KMO (0.58) | KMT2AMEN1MAPTLMNAALDH1A1 | |
| SCHEMBL30354785 | 0.79 | KDM4E (0.53) | KMT2AMEN1CYTH2MAPTLMNA | |
| SCHEMBL2180207 | 0.78 | CA2 (0.53) | KMT2AMEN1CYTH2ALDH1A1CA2 | |
| SCHEMBL3925744 | 0.76 | LMNA (0.78) | KMT2ALMNAALDH1A1SMN1; SMN2CA2 | |
| SCHEMBL5942928 | 0.76 | ALDH1A1 (0.68) | KMT2AMEN1CYTH2MAPTALDH1A1 | |
| SCHEMBL30978874 | 0.76 | ALDH1A1 (0.72) | KMT2AMEN1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL12904222 | 0.75 | KMT2A (0.66) | KMT2AMEN1CYTH2LMNAALDH1A1 | |
| SCHEMBL2179378 | 0.75 | ALDH1A1 (0.61) | KMT2AMEN1MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2013-01-24 | — | — | US | disclosed |
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2013-01-24 | — | — | US | disclosed |
| WO-2011082400-A2 | MODULATORS OF IMMUNOINHIBITORY RECEPTOR PD-1, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-07-07 | — | — | WO | disclosed |
| WO-2011082400-A2 | MODULATORS OF IMMUNOINHIBITORY RECEPTOR PD-1, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | CD274, PDCD1LG2, PDCD1 | KMT2A 3860/4885MEN1 4011/4885CYTH2 970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.