Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 5/20 | 0.43 |
| ▸ | CALM1 | P0DP23 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7905163 | 0.67 | TP53 (0.46) | MAPTSMN1; SMN2TP53HPGDKDM4E | |
| SCHEMBL7915034 | 0.66 | MAPT (0.48) | MAPTSMN1; SMN2TP53HPGDKDM4E | |
| SCHEMBL5724043 | 0.65 | CYP1A1 (0.48) | MAPTSMN1; SMN2TP53HPGDKDM4E | |
| Acetamide SCHEMBL4060765 | 0.62 | MAPT (0.44) | MAPTSMN1; SMN2TP53HPGDKDM4E | |
| Flavanone SCHEMBL980197 | 0.62 | TP53 (1.00) | MAPTSMN1; SMN2TP53HPGDKDM4E | |
| Flavanone SCHEMBL29678059 | 0.62 | TP53 (1.00) | MAPTSMN1; SMN2TP53HPGDKDM4E | |
| SCHEMBL15944379 | 0.61 | ALDH1A1 (0.65) | MAPTSMN1; SMN2TP53HPGDKDM4E | |
| SCHEMBL13034004 | 0.61 | MAPT (0.46) | MAPTSMN1; SMN2TP53HPGDKDM4E | |
| 6-Hydroxyflavone SCHEMBL29628861 | 0.61 | MAPT (1.00) | MAPTSMN1; SMN2TP53HPGDKDM4E | |
| 6-Hydroxyflavone SCHEMBL676594 | 0.61 | MAPT (1.00) | MAPTSMN1; SMN2TP53HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11331313-B2 | KCC2 expression enhancing compounds and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2022-05-17 | — | — | US | disclosed |
| US-20200085817-A1 | KCC2 EXPRESSION ENHANCING COMPOUNDS AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2020-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11331313-B2 | KCC2 expression enhancing compounds and uses thereof | MECP2, SLC1A2, GRIN2C | MAPT 1725/4885SMN1; SMN2 731/4885TP53 4146/4885 |
| US-20200085817-A1 | KCC2 EXPRESSION ENHANCING COMPOUNDS AND USES THEREOF | MECP2, SLC1A2, GRIN2C | MAPT 1725/4885SMN1; SMN2 731/4885TP53 4146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.