Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7604494 | 0.92 | CYP3A4 (0.36) | HTTCYP3A4SMN1; SMN2SMYD2NPC1 | |
| SCHEMBL25062385 | 0.91 | ALOX5 (0.36) | HTTCYP3A4SMN1; SMN2SMYD2JAK3 | |
| SCHEMBL31528857 | 0.90 | CYP3A4 (0.35) | HTTCYP3A4SMN1; SMN2SMYD2HDAC4 | |
| SCHEMBL31528924 | 0.90 | CYP3A4 (0.35) | HTTCYP3A4SMN1; SMN2SMYD2HDAC4 | |
| SCHEMBL31528877 | 0.90 | CYP3A4 (0.35) | HTTCYP3A4SMN1; SMN2SMYD2HDAC4 | |
| SCHEMBL1291772 | 0.81 | LMNA (0.42) | HTTCYP3A4SMN1; SMN2SMYD2BLM | |
| SCHEMBL1291773 | 0.80 | LMNA (0.40) | HTTCYP3A4SMN1; SMN2SMYD2KDM4E | |
| SCHEMBL9156477 | 0.80 | SMYD2 (0.41) | HTTCYP3A4SMN1; SMN2SMYD2ALDH1A1 | |
| SCHEMBL31122926 | 0.79 | JAK3 (0.33) | HTTCYP3A4SMN1; SMN2SMYD2JAK3 | |
| SCHEMBL14296551 | 0.79 | JAK3 (0.37) | HTTCYP3A4SMN1; SMN2SMYD2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3559007-B1 | SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY | DAIICHI SANKYO CO LTD (JP) | 2023-08-16 | — | — | EP | disclosed |
| CN-110167946-B | Sulfonamide compounds having TNAP inhibitory activity | 第一三共株式会社 | 2022-04-08 | — | — | CN | disclosed |
| US-11046710-B2 | Sulfonamide compounds | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-06-29 | — | — | US | disclosed |
| US-11014939-B2 | — | — | 2021-05-25 | — | — | US | disclosed |
| US-20200087321-A1 | SULFONAMIDE COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200087321-A1 | SULFONAMIDE COMPOUNDS | ALPI, ASAH2, STS | HTT 4598/4885CYP3A4 1108/4885SMN1; SMN2 2383/4885 |
| US-11014939-B2 | — | ALPI, ALPP, ACER2 | HTT 4589/4885CYP3A4 1696/4885SMN1; SMN2 3344/4885 |
| US-11046710-B2 | Sulfonamide compounds | ALPI, ASAH2, STS | HTT 4598/4885CYP3A4 1108/4885SMN1; SMN2 2383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.