Sugi Predict

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SCHEMBL2180240

SCHEMBL2180240

CC(C)C(C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)c4ccc(Cl)cc4Cl)cc3)cc2C1=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SDCBP O00560 3/20 0.48
▸ SDC2 P34741 3/20 0.48
▸ RAB9A P51151 2/20 0.46
▸ MEN1 O00255 4/20 0.46
▸ KMT2A Q03164 4/20 0.46
▸ ATM Q13315 1/20 0.44
▸ GPR27 Q9NS67 3/20 0.43
▸ AVPR2 P30518 2/20 0.43
▸ MAPT P10636 1/20 0.42
▸ CYP2C19 P33261 1/20 0.42
▸ GAA P10253 1/20 0.41
▸ POLB P06746 1/20 0.41
▸ JAK2 O60674 1/20 0.41
▸ JAK1 P23458 1/20 0.41
▸ TYK2 P29597 1/20 0.41
▸ LMNA P02545 1/20 0.41
▸ TP53 P04637 1/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ ALDH1A1 P00352 1/20 0.40
▸ HSD11B1 P28845 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13719075 1.00 SDCBP (0.48) SDCBPSDC2RAB9AMEN1KMT2A
SCHEMBL2177068 0.90 SMO (0.53) SDCBPSDC2RAB9AMAPTLMNA
SCHEMBL2181361 0.90 SMO (0.53) SDCBPSDC2RAB9AMAPTLMNA
SCHEMBL2178384 0.88 SDCBP (0.48) SDCBPSDC2RAB9ALMNATP53
SCHEMBL2178377 0.88 SDCBP (0.48) SDCBPSDC2RAB9ALMNATP53
SCHEMBL2177018 0.85 ACHE (0.46) SDCBPSDC2RAB9AMEN1KMT2A
SCHEMBL2177024 0.85 ACHE (0.46) SDCBPSDC2RAB9AMEN1KMT2A
SCHEMBL13719026 0.85 LMNA (0.44) SDCBPSDC2MAPTLMNATP53
SCHEMBL2179082 0.85 LMNA (0.44) SDCBPSDC2MAPTLMNATP53
SCHEMBL13718795 0.85 SMO (0.44) SDCBPSDC2MAPTLMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8748426-B2 Inhibitors of diacylglycerol acyl transferase Piramal Enterprises Limited (IN) 2014-06-10 — — US claimed
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Enterprises Limited (IN) 2012-11-15 — — US claimed
EP-2519500-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Healthcare Ltd. (IN) 2012-11-07 — — EP claimed
WO-2011080718-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-07-07 — — WO claimed
US-8748426-B2 Inhibitors of diacylglycerol acyl transferase Piramal Enterprises Limited (IN) 2014-06-10 — — US disclosed
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Enterprises Limited (IN) 2012-11-15 — — US disclosed
EP-2519500-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Healthcare Ltd. (IN) 2012-11-07 — — EP disclosed
WO-2011080718-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-07-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE DGAT1, DGAT2, LCAT SDCBP 2373/4885SDC2 3855/4885RAB9A 2039/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.