Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22188710 | 0.83 | ADRB2 (0.39) | CHRNB2CHRNA4 | |
| SCHEMBL3624304 | 0.79 | KMT2A (0.38) | — | |
| SCHEMBL21815523 | 0.64 | HPGD (0.38) | CHRNB2CHRNA4 | |
| SCHEMBL21815525 | 0.63 | HPGD (0.43) | CHRNB2CHRNA4 | |
| SCHEMBL28200382 | 0.63 | HPGD (0.33) | — | |
| Tert-Butyl Formate SCHEMBL28289206 | 0.60 | SIGMAR1 (0.42) | — | |
| SCHEMBL21815529 | 0.60 | RAB9A (0.35) | CHRNB2CHRNA4 | |
| SCHEMBL4125494 | 0.60 | CYP2B6 (0.41) | — | |
| SCHEMBL27936066 | 0.58 | HTR3E (0.36) | — | |
| SCHEMBL21815524 | 0.58 | CHRM2 (0.36) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3856348-A1 | PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS ALK2 ABD/OR FGFR MODULATORS | Incyte Corporation (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020068729-A1 | PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS ALK2 ABD/OR FGFR MODULATORS | INCYTE CORPORATION (US) | 2020-04-02 | — | — | WO | disclosed |