Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 3/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.34 |
| ▸ | RET | P07949 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.34 |
| ▸ | BCR | P11274 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | FES | P07332 | 2/20 | 0.34 |
| ▸ | LYN | P07948 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22188711 | 0.83 | RAB9A (0.41) | RAB9AHPGDMKNK1MKNK2AURKA | |
| SCHEMBL3624311 | 0.79 | CHRM1 (0.52) | RAB9AAURKAABL1NTRK1RET | |
| Hydrochloric Acid SCHEMBL25272684 | 0.78 | CHRM1 (0.51) | RAB9AAURKAABL1NTRK1RET | |
| Hydrochloric Acid SCHEMBL25272683 | 0.78 | CHRM1 (0.51) | RAB9AAURKAABL1NTRK1RET | |
| SCHEMBL20533596 | 0.71 | CA2 (0.38) | OPRD1CYP3A4 | |
| SCHEMBL8606865 | 0.71 | HPGD (0.44) | RAB9AHPGDOPRD1 | |
| SCHEMBL21815527 | 0.69 | OPRD1 (0.39) | MKNK1MKNK2CLK4OPRD1CHRNB2 | |
| SCHEMBL20448931 | 0.68 | ALDH1A1 (0.43) | RAB9AMKNK1MKNK2SIGMAR1CHRNB2 | |
| SCHEMBL7978722 | 0.68 | CA2 (0.42) | HPGDSIGMAR1CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL3800402 | 0.66 | TSHR (0.43) | HPGDMKNK1MKNK2SIGMAR1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3856348-A1 | PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS ALK2 ABD/OR FGFR MODULATORS | Incyte Corporation (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020068729-A1 | PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS ALK2 ABD/OR FGFR MODULATORS | INCYTE CORPORATION (US) | 2020-04-02 | — | — | WO | disclosed |