Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 4/20 | 0.52 |
| ▸ | CA6 | P23280 | 4/20 | 0.52 |
| ▸ | CA7 | P43166 | 4/20 | 0.52 |
| ▸ | CA9 | Q16790 | 4/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | CA4 | P22748 | 3/20 | 0.52 |
| ▸ | CA5A | P35218 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | CASP2 | P42575 | 2/20 | 0.52 |
| ▸ | F13A1 | P00488 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | THPO | P40225 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL323710 | 0.91 | TDP1 (0.61) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL323463 | 0.91 | CYP2C19 (0.58) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL7522951 | 0.89 | ALOX15 (0.56) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL427900 | 0.89 | TDP1 (0.59) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL30607521 | 0.88 | CYP2C19 (0.56) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL11871853 | 0.88 | CYP2C19 (0.56) | TDP1CA12CA6CA7CA9 | |
| Hydrochloric Acid SCHEMBL6114403 | 0.87 | UBE2N (0.58) | TDP1CA12CA6CA7CA9 | |
| Hydrochloric Acid SCHEMBL28341342 | 0.87 | UBE2N (0.58) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL10123951 | 0.86 | CYP2C19 (0.58) | TDP1CA12CA6CA7CA9 | |
| SCHEMBL11323396 | 0.85 | PAOX (0.48) | TDP1CA12CA6CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-07 | — | — | US | claimed |
| WO-2010014798-A2 | PYRIMIDOTRIAZINEDIONES AND PYRIMIDOPYRIMIDINEDIONES AND METHODS OF USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-02-04 | — | — | WO | claimed |
| US-20230181524-A1 | PHARMACEUTICAL COMBINATION AND USE THEREOF | NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD. (CN) | 2023-06-15 | — | — | US | disclosed |
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-07 | — | — | US | disclosed |
| WO-2010014798-A2 | PYRIMIDOTRIAZINEDIONES AND PYRIMIDOPYRIMIDINEDIONES AND METHODS OF USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-02-04 | — | — | WO | disclosed |
| US-5639582-A | Electrophotographic toner composition and process for the preparation thereof | FUJI XEROX CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0017122-B1 | USE OF VONEL QUATERNARY POLYSILOXANE DERIVATIVES IN HAIR COSMETICS, AND HAIR WASHING AND HAIR TREATMENT COMPOSITIONS CONTAINING THEM | Henkel Kommanditgesellschaft auf Aktien (DE) | 1983-06-15 | — | — | EP | disclosed |
| EP-0017121-B1 | QUATERNARY POLYSILOXANE DERIVATIVES, THEIR USE IN HAIR COSMETICS, AND HAIR WASHING AND HAIR TREATMENT COMPOSITIONS CONTAINING THEM | Henkel Kommanditgesellschaft auf Aktien (DE) | 1983-04-20 | — | — | EP | disclosed |
| EP-0017122-A1 | Use of vonel quaternary polysiloxane derivatives in hair cosmetics, and hair washing and hair treatment compositions containing them | Henkel Kommanditgesellschaft auf Aktien (DE) | 1980-10-15 | — | — | EP | disclosed |
| EP-0017121-A1 | Quaternary polysiloxane derivatives, their use in hair cosmetics, and hair washing and hair treatment compositions containing them | Henkel Kommanditgesellschaft auf Aktien (DE) | 1980-10-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230181524-A1 | PHARMACEUTICAL COMBINATION AND USE THEREOF | TCF4, TCF7L2, CTNNB1 | TDP1 3665/4885CA12 1352/4885CA6 1027/4885 |
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | DPYD, TYMP, DHFR | TDP1 941/4885CA12 3644/4885CA6 1357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.