Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.56 |
| ▸ | CA12 | O43570 | 3/20 | 0.56 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | CA4 | P22748 | 3/20 | 0.56 |
| ▸ | CA6 | P23280 | 3/20 | 0.56 |
| ▸ | CA5A | P35218 | 3/20 | 0.56 |
| ▸ | CA7 | P43166 | 3/20 | 0.56 |
| ▸ | CA9 | Q16790 | 3/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.56 |
| ▸ | F13A1 | P00488 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | THPO | P40225 | 2/20 | 0.56 |
| ▸ | CASP2 | P42575 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28341342 | 0.98 | UBE2N (0.58) | TDP1ALOX15CA12CA2CA4 | |
| Hydrochloric Acid SCHEMBL6114403 | 0.98 | UBE2N (0.58) | TDP1ALOX15CA12CA2CA4 | |
| SCHEMBL323710 | 0.98 | TDP1 (0.61) | TDP1ALOX15CA12CA2CA4 | |
| SCHEMBL7522951 | 0.96 | ALOX15 (0.56) | TDP1ALOX15CA12CA2CA4 | |
| SCHEMBL4562189 | 0.96 | PAOX (0.55) | TDP1ALOX15CA12CA2CA4 | |
| SCHEMBL4562729 | 0.94 | PAOX (0.58) | TDP1ALOX15CA12CA2CA4 | |
| SCHEMBL4561516 | 0.94 | PAOX (0.58) | TDP1ALOX15CA12CA2CA4 | |
| SCHEMBL322792 | 0.91 | ALOX15 (0.54) | TDP1ALOX15CA12CA2CA4 | |
| SCHEMBL4562850 | 0.91 | PAOX (0.53) | TDP1ALOX15CA12CA2CA4 | |
| SCHEMBL322920 | 0.89 | PAOX (0.53) | TDP1ALOX15CA12CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016125163-A1 | LIPID ASSEMBLIES AND USES THEREOF AND SOME pH AND ELECTROSTATIC MODULATING LIPIDS TO BE USED IN SAID ASSEMBLIES | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2016-08-11 | — | — | WO | claimed |
| WO-2013122751-A1 | COMPOSITIONS AND METHODS FOR CONTRACEPTION | FIRESTONE, RAYMOND, A. (US) | 2013-08-22 | — | — | WO | claimed |
| EP-1937235-A2 | METHODS FOR TREATING VIRAL INFECTIONS USING POLYAMINE ANALOGS | Pathologica, LLC. (US) | 2008-07-02 | — | — | EP | claimed |
| US-20070078187-A1 | METHODS FOR TREATING VIRAL INFECTIONS USING POLYAMINE ANALOGS | PATHOLOGICA, LLC. (US) | 2007-04-05 | — | — | US | claimed |
| WO-2007035957-A2 | METHODS FOR TREATING VIRAL INFECTIONS USING POLYAMINE ANALOGS | PATHOLOGICA, LLC. (US) | 2007-03-29 | — | — | WO | claimed |
| US-7087648-B1 | Methods for modulating macrophage proliferation using polyamine analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-08-08 | — | — | US | claimed |
| US-20050159493-A1 | Methods for modulating macrophage proliferation using polyamine analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2005-07-21 | — | — | US | claimed |
| US-20050113455-A1 | Method and composition for amelioration of pain | UNIVERSITY OF FLORIDA | 2005-05-26 | — | — | US | claimed |
| WO-2005041988-A1 | METHOD AND COMPOSITION FOR PAIN AMELIORATION | UNIVERSITY OF FLORIDA (US) | 2005-05-12 | — | — | WO | claimed |
| JP-2001520990-A | — | — | 2001-11-06 | — | — | JP | claimed |
| EP-1027040-A2 | METHODS FOR MODULATING MACROPHAGE PROLIFERATION USING POLYAMINE ANALOGS | The Regents of the University of California (US) | 2000-08-16 | — | — | EP | claimed |
| WO-1999021542-A2 | METHODS FOR MODULATING MACROPHAGE PROLIFERATION USING POLYAMINE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-05-06 | — | — | WO | claimed |
| EP-0536853-B1 | Process for the preparation of N1,N4-diethylspermine | UNIV FLORIDA (US) | 1996-03-27 | — | — | EP | claimed |
| US-5498522-A | ANTITUMOR AGENTS OR ANTICARCINOGENIC AGENTS | HEALTH RESEARCH, INC. (US) | 1996-03-12 | — | — | US | claimed |
| EP-0568338-A2 | Methods for the use of spermidine/spermine N'-acetyltransferase as a progonostic indicator and/or a tumor response marker | HEALTH RESEARCH, INC. (US) | 1993-11-03 | — | — | EP | claimed |
| EP-0270349-B1 | USE OF AN ANTI-NEOPLASTIC SPERMINE DERIVATIVE IN THE PREPARATION OF A PHARMACEUTICAL COMPOSITION | UNIV FLORIDA (US) | 1993-08-04 | — | — | EP | claimed |
| EP-0536853-A2 | Process for the preparation of N1,N4-diethylspermine | THE UNIVERSITY OF FLORIDA (US) | 1993-04-14 | — | — | EP | claimed |
| EP-0270349-A2 | Use of an anti-neoplastic spermine derivative in the preparation of a pharmaceutical composition | THE UNIVERSITY OF FLORIDA (US) | 1988-06-08 | — | — | EP | claimed |
| JP-6062896-A | — | — | None | — | — | JP | disclosed |
| EP-0270349-A2 | Use of an anti-neoplastic spermine derivative in the preparation of a pharmaceutical composition | THE UNIVERSITY OF FLORIDA (US) | 1988-06-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078187-A1 | METHODS FOR TREATING VIRAL INFECTIONS USING POLYAMINE ANALOGS | GLS, SHMT2, ARG2 | TDP1 1614/4885ALOX15 2716/4885CA12 3056/4885 |
| US-20050113455-A1 | Method and composition for amelioration of pain | SIGMAR1, ADORA2B, OPRL1 | TDP1 3234/4885ALOX15 2427/4885CA12 1722/4885 |
| US-20050159493-A1 | Methods for modulating macrophage proliferation using polyamine analogs | ARG1, MKI67, CSF1R | TDP1 1008/4885ALOX15 814/4885CA12 2986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.