Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 8/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707540 | 0.94 | LMNA (0.46) | LMNAMAPTMAPK1EGFRHTT | |
| SCHEMBL13536721 | 0.91 | MAPK1 (0.44) | LMNAMAPK1EGFRHTTKDM4E | |
| SCHEMBL2182737 | 0.90 | ALDH1A1 (0.49) | LMNAMAPK1EGFRHTTKDM4E | |
| SCHEMBL2184357 | 0.89 | EGFR (0.43) | LMNAMAPK1EGFRHTTKDM4E | |
| SCHEMBL1842823 | 0.89 | GAA (0.44) | LMNAMAPK1EGFRHTTKDM4E | |
| SCHEMBL1706635 | 0.86 | LMNA (0.39) | LMNAMAPTMAPK1EGFRHTT | |
| SCHEMBL2184566 | 0.85 | SLC6A4 (0.40) | LMNAMAPK1EGFRHTTKDM4E | |
| SCHEMBL1841173 | 0.85 | HTT (0.45) | LMNAEGFRHTTKDM4EHPGD | |
| SCHEMBL1707897 | 0.83 | ALDH1A1 (0.49) | LMNAMAPK1EGFRHTTKDM4E | |
| SCHEMBL1839128 | 0.83 | NSD2 (0.46) | LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841311-B2 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-09-23 | — | — | US | disclosed |
| US-8841311-B2 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-09-23 | — | — | US | disclosed |
| US-8841311-B2 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-09-23 | — | — | US | disclosed |
| EP-2321284-B1 | SULFONE SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNE-MODULATORS FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES | Bayer Pharma AG (DE) | 2012-05-09 | — | — | EP | disclosed |
| US-20110166168-A1 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-07-07 | — | — | US | disclosed |
| US-20110166168-A1 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-07-07 | — | — | US | disclosed |
| US-20110166168-A1 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166168-A1 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | TPMT, IFNG, HLA-DRB1 | LMNA 4875/4885MAPT 3160/4885MAPK1 2766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.