Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.54 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 7/20 | 0.46 |
| ▸ | PPARD | Q03181 | 7/20 | 0.46 |
| ▸ | PPARA | Q07869 | 7/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TLR2 | O60603 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | FABP4 | P15090 | 2/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL28497561 | 0.96 | GPR84 (0.62) | GPR84FFAR1FFAR4LMNACAMK2A | |
| Adipic Acid SCHEMBL230983 | 0.95 | LMNA (0.58) | GPR84FFAR1FFAR4LMNATSHR | |
| Adipic Acid SCHEMBL3475386 | 0.95 | LMNA (0.58) | GPR84FFAR1FFAR4LMNATSHR | |
| Adipic Acid SCHEMBL8898737 | 0.93 | GPR84 (0.65) | GPR84FFAR1FFAR4LMNACAMK2A | |
| Octanedioate SCHEMBL31742463 | 0.93 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR | |
| SCHEMBL30302267 | 0.93 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR | |
| Pimelic Acid SCHEMBL30288546 | 0.93 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR | |
| Sebacic Acid SCHEMBL11387993 | 0.93 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR | |
| SCHEMBL29227501 | 0.93 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR | |
| Azelaic Acid SCHEMBL8594583 | 0.93 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116041657-A | Synthesis method of internal crosslinking type cationic aqueous polyurethane emulsion | 中国科学院山西煤炭化学研究所 | 2023-05-02 | — | — | CN | claimed |
| CN-113956428-A | Novel polyurethane material and preparation method thereof | 中国科学院山西煤炭化学研究所 | 2022-01-21 | — | — | CN | claimed |
| CN-111269613-B | Gravure printing water-based ink and preparation method thereof | 广东佰合新材料科技股份有限公司 | 2021-12-21 | — | — | CN | claimed |
| CN-109456459-B | Method for improving water resistance or solvent resistance of waterborne polyurethane | 中国科学院山西煤炭化学研究所 | 2021-06-29 | — | — | CN | claimed |
| CN-111662423-A | Preparation method of hydroxyl functionalized waterborne polyurethane | 中国科学院山西煤炭化学研究所 | 2020-09-15 | — | — | CN | claimed |
| CN-111269613-A | Gravure printing water-based ink and preparation method thereof | 广东佰合新材料科技股份有限公司 | 2020-06-12 | — | — | CN | claimed |
| WO-2020062327-A1 | NON-IONIC SILICON-CONTAINING AQUEOUS POLYURETHANE DISPERSION, PREPARATION THEREFOR AND APPLICATION THEREOF IN HAIR CLEANING | 上海万华科聚化工科技发展有限公司 | 2020-04-02 | — | — | WO | claimed |
| CN-110862336-A | Alcohol amine chain extender, preparation method and application | 中国科学院山西煤炭化学研究所 | 2020-03-06 | — | — | CN | claimed |
| CN-110862506-A | Synthetic method of waterborne polyurethane primer | 中国科学院山西煤炭化学研究所 | 2020-03-06 | — | — | CN | claimed |
| CN-112433455-B | Developing member, electrophotographic process cartridge, and electrophotographic image forming apparatus | 佳能株式会社 | 2023-09-26 | — | — | CN | disclosed |
| CN-116041657-A | Synthesis method of internal crosslinking type cationic aqueous polyurethane emulsion | 中国科学院山西煤炭化学研究所 | 2023-05-02 | — | — | CN | disclosed |
| CN-113980218-A | Moisture-curing polyurethane hot-melt adhesive and preparation method and application thereof | 河南省科学院化学研究所有限公司 | 2022-01-28 | — | — | CN | disclosed |
| CN-113956428-A | Novel polyurethane material and preparation method thereof | 中国科学院山西煤炭化学研究所 | 2022-01-21 | — | — | CN | disclosed |
| CN-111269613-B | Gravure printing water-based ink and preparation method thereof | 广东佰合新材料科技股份有限公司 | 2021-12-21 | — | — | CN | disclosed |
| CN-109456459-B | Method for improving water resistance or solvent resistance of waterborne polyurethane | 中国科学院山西煤炭化学研究所 | 2021-06-29 | — | — | CN | disclosed |
| CN-112824978-A | Cleaning blade, process cartridge, and image forming apparatus | 株式会社理光 | 2021-05-21 | — | — | CN | disclosed |
| CN-111662423-A | Preparation method of hydroxyl functionalized waterborne polyurethane | 中国科学院山西煤炭化学研究所 | 2020-09-15 | — | — | CN | disclosed |
| CN-111269613-A | Gravure printing water-based ink and preparation method thereof | 广东佰合新材料科技股份有限公司 | 2020-06-12 | — | — | CN | disclosed |
| CN-110862336-A | Alcohol amine chain extender, preparation method and application | 中国科学院山西煤炭化学研究所 | 2020-03-06 | — | — | CN | disclosed |
| CN-110862506-A | Synthetic method of waterborne polyurethane primer | 中国科学院山西煤炭化学研究所 | 2020-03-06 | — | — | CN | disclosed |