Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.65 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.65 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.65 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 7/20 | 0.44 |
| ▸ | PPARD | Q03181 | 7/20 | 0.44 |
| ▸ | PPARA | Q07869 | 7/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL2487662 | 0.98 | GPR84 (0.70) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Sebacic Acid SCHEMBL28249080 | 0.98 | GPR84 (0.70) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Adipic Acid SCHEMBL28497561 | 0.98 | GPR84 (0.62) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Adipic Acid SCHEMBL21834595 | 0.93 | GPR84 (0.54) | GPR84FFAR1FFAR4CAMK2ALMNA | |
| Adipic Acid SCHEMBL3475386 | 0.93 | LMNA (0.58) | GPR84FFAR1FFAR4LMNATSHR | |
| Adipic Acid SCHEMBL230983 | 0.93 | LMNA (0.58) | GPR84FFAR1FFAR4LMNATSHR | |
| Octanedioate SCHEMBL31742463 | 0.91 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR | |
| SCHEMBL30302267 | 0.91 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR | |
| Pimelic Acid SCHEMBL30288546 | 0.91 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR | |
| Sebacic Acid SCHEMBL11387993 | 0.91 | TSHR (0.60) | GPR84FFAR1FFAR4LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112745795-B | Waterborne polyurethane electrostatic flocking adhesive for injection molding and preparation method | 辽宁恒星精细化工有限公司 | 2022-07-15 | — | — | CN | claimed |
| CN-112745795-A | Waterborne polyurethane electrostatic flocking adhesive for injection molding and preparation method | 辽宁恒星精细化工有限公司 | 2021-05-04 | — | — | CN | claimed |
| CN-109294208-A | Photochromic urethane composition and its preparation method and application, the color-changing lens comprising it | 上海康耐特光学有限公司 | 2019-02-01 | — | — | CN | claimed |
| CN-105884999-B | Preparation method and products thereof containing hydrophilic and hydrophobic side long-chain modified cation aqueous polyurethane emulsion | 武汉纺织大学 | 2018-08-21 | — | — | CN | claimed |
| CN-105884999-A | Preparation method of modified cation waterborne polyurethane emulsion containing hydrophilic and hydrophobic side long chains and product thereof | 武汉纺织大学 | 2016-08-24 | — | — | CN | claimed |
| CN-112795325-B | Wear-resisting resistant stealthy car clothing that deforms | 广东粤港澳大湾区黄埔材料研究院 | 2022-11-08 | — | — | CN | disclosed |
| CN-112745795-B | Waterborne polyurethane electrostatic flocking adhesive for injection molding and preparation method | 辽宁恒星精细化工有限公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-113605091-A | Carboxylate type waterborne polyurethane fabric coating agent based on polyester/polyether and preparation method thereof | 华南理工大学 | 2021-11-05 | — | — | CN | disclosed |
| CN-113072679-A | Radiation-curable benzophenone end-capped polyurethane resin and application thereof | 深圳力合博汇光敏材料有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-112795325-A | Wear-resisting resistant stealthy car clothing that deforms | 中科院长春应化所黄埔先进材料研究院 | 2021-05-14 | — | — | CN | disclosed |
| CN-112745795-A | Waterborne polyurethane electrostatic flocking adhesive for injection molding and preparation method | 辽宁恒星精细化工有限公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-105884999-B | Preparation method and products thereof containing hydrophilic and hydrophobic side long-chain modified cation aqueous polyurethane emulsion | 武汉纺织大学 | 2018-08-21 | — | — | CN | disclosed |
| CN-105884999-A | Preparation method of modified cation waterborne polyurethane emulsion containing hydrophilic and hydrophobic side long chains and product thereof | 武汉纺织大学 | 2016-08-24 | — | — | CN | disclosed |
| CN-101600747-A | The polyurethane composition of silanization and tackiness agent therefrom | MOMENTIVE PERFORMANCE MAT INC (US) | 2009-12-09 | — | — | CN | disclosed |
| US-5618904-A | REACTION PRODUCT OF POLYESTER POLYOL OR MIXTURE OF POLYESTER POLYOL AND POLYETHER POLYOL, POLYISOCYANATE, HYDROQUINONE BIS/2-HYDROXYETHYL/ ETHER | ESSEX SPECIALTY PRODUCTS INC. (US) | 1997-04-08 | — | — | US | disclosed |