Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | S100B | P04271 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 3/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21835728 | 0.83 | SMN1; SMN2 (0.39) | TDP1ALDH1A1TSHRRORCNPC1 | |
| SCHEMBL29754231 | 0.81 | RORC (0.34) | ALDH1A1RORCNPC1MAPTRAB9A | |
| SCHEMBL24869826 | 0.80 | CYP3A4 (0.43) | TDP1ALDH1A1CYP3A4TSHRS100B | |
| SCHEMBL16756041 | 0.80 | ALDH1A1 (0.46) | TDP1ALDH1A1CYP3A4TSHRS100B | |
| SCHEMBL4426535 | 0.78 | ALDH1A1 (0.45) | TDP1ALDH1A1CYP3A4TSHRS100B | |
| SCHEMBL7443836 | 0.77 | TDP1 (0.44) | TDP1ALDH1A1CYP3A4TSHRS100B | |
| Hydrochloric Acid SCHEMBL29492790 | 0.77 | ALDH1A1 (0.43) | TDP1ALDH1A1CYP3A4TSHRS100B | |
| SCHEMBL14322000 | 0.76 | PDIA6 (0.54) | TDP1ALDH1A1RORCL3MBTL1SMN1; SMN2 | |
| SCHEMBL11238 | 0.76 | TDP1 (0.43) | TDP1ALDH1A1CYP3A4TSHRNPC1 | |
| SCHEMBL11433 | 0.76 | TDP1 (0.43) | TDP1ALDH1A1CYP3A4TSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210403476-A1 | ION CHANNEL MODULATORS | PRAXIS PRECISION MEDICINES, INC. | 2021-12-30 | — | — | US | disclosed |
| EP-3856193-A1 | ION CHANNEL MODULATORS | Praxis Precision Medicines, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020069322-A1 | ION CHANNEL MODULATORS | PRAXIS PRECISION MEDICINES, INC. (US) | 2020-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210403476-A1 | ION CHANNEL MODULATORS | SCN1A, SCN3A, SCN2A | TDP1 3478/4885ALDH1A1 1953/4885CYP3A4 3388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.