Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21837294 | 0.88 | PRMT6 (0.33) | GPR119PDPK1BRD4PRMT6ADORA1 | |
| SCHEMBL17465401 | 0.84 | BRD4 (0.35) | PDPK1BRD4AURKARPS6KB1ADORA3 | |
| SCHEMBL21837304 | 0.82 | ADORA3 (0.36) | BRD4AURKARPS6KB1ADORA3ADORA1 | |
| SCHEMBL21837309 | 0.79 | GPR119 (0.32) | GPR119PDPK1BRD4AURKARPS6KB1 | |
| SCHEMBL17453456 | 0.79 | RPS6KB1 (0.31) | GPR119PDPK1AURKARPS6KB1 | |
| SCHEMBL17479810 | 0.78 | GPR119 (0.30) | GPR119 | |
| SCHEMBL21837302 | 0.76 | GPR119 (0.31) | GPR119 | |
| SCHEMBL21837311 | 0.76 | — | — | |
| SCHEMBL17468596 | 0.75 | PDE4A (0.35) | AURKARPS6KB1PRMT6 | |
| SCHEMBL17453474 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4023650-A1 | 4'-SUBSTITUTED-FURO[3,2-D]PYRIMIDINE AND -PYRROLO[3,2- D]PYRIMIDINE DERIVATIVES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | Gilead Sciences, Inc. (US) | 2022-07-06 | — | — | EP | disclosed |
| EP-3174870-B1 | THIENO [3,2-D]PYRIMIDINES, FURO [3,2,D]PYRIMIDINES AND PYRROLO [3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES INC (US) | 2020-04-15 | — | — | EP | disclosed |