Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | STAT3 | P40763 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26816572 | 0.84 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1NPSR1KDM4EHPGD | |
| SCHEMBL8930615 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1NPSR1KDM4EHPGD | |
| SCHEMBL30668842 | 0.79 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1NPSR1KDM4EHPGD | |
| SCHEMBL9298896 | 0.79 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1NPSR1KDM4EHPGD | |
| SCHEMBL26816560 | 0.79 | HTT (0.58) | SMN1; SMN2ALDH1A1NPSR1KDM4EHPGD | |
| SCHEMBL21851973 | 0.76 | TP53 (0.57) | SMN1; SMN2ALDH1A1NPSR1KDM4EHPGD | |
| SCHEMBL24499459 | 0.74 | SMN1; SMN2 (0.73) | SMN1; SMN2ALDH1A1NPSR1KDM4EHPGD | |
| SCHEMBL27896148 | 0.74 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1NPSR1KDM4EHPGD | |
| SCHEMBL1118436 | 0.74 | SMN1; SMN2 (0.73) | SMN1; SMN2ALDH1A1NPSR1KDM4EHPGD | |
| SCHEMBL29466463 | 0.74 | SMN1; SMN2 (0.73) | SMN1; SMN2ALDH1A1NPSR1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11324731-B2 | TXNIP-TRX complex inhibitors and methods of using the same | CITY OF HOPE (US) | 2022-05-10 | — | — | US | disclosed |
| US-20200085800-A1 | TXNIP-TRX COMPLEX INHIBITORS AND METHODS OF USING THE SAME | CITY OF HOPE | 2020-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11324731-B2 | TXNIP-TRX complex inhibitors and methods of using the same | TXN, TXN2, TXNRD3 | SMN1; SMN2 3405/4885ALDH1A1 3479/4885NPSR1 4610/4885 |
| US-20200085800-A1 | TXNIP-TRX COMPLEX INHIBITORS AND METHODS OF USING THE SAME | TXN, TXN2, TXNRD3 | SMN1; SMN2 3405/4885ALDH1A1 3479/4885NPSR1 4610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.