Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 13/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 13/20 | 0.34 |
| ▸ | RRM1 | P23921 | 13/20 | 0.34 |
| ▸ | RRM2B | Q7LG56 | 13/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21853512 | 1.00 | SORT1 (0.38) | SORT1NOTUMCHRM2CHRM1RRM1 | |
| SCHEMBL20872545 | 0.69 | CHRM2 (0.67) | CHRM2CHRM1RRM1RRM2B | |
| SCHEMBL20773326 | 0.65 | NOTUM (0.40) | NOTUM | |
| SCHEMBL20837406 | 0.65 | ALDH1A1 (0.41) | SORT1NOTUM | |
| SCHEMBL21853485 | 0.64 | GFER (0.40) | — | |
| SCHEMBL21853487 | 0.64 | GFER (0.40) | — | |
| SCHEMBL18010971 | 0.64 | CTSK (0.44) | NOTUM | |
| SCHEMBL452633 | 0.64 | RIPK1 (0.50) | — | |
| SCHEMBL17582100 | 0.64 | RIPK1 (0.50) | — | |
| SCHEMBL18010976 | 0.63 | ATM (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365524-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-16 | — | — | US | disclosed |
| US-11713304-B2 | 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH | BAYER AKTIENGESELLSCHAFT (DE) | 2023-08-01 | — | — | US | disclosed |
| US-20220135536-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AKTIENGESELLSCHAFT (DE) | 2022-05-05 | — | — | US | disclosed |
| EP-3532468-B1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AG (DE) | 2022-03-23 | — | — | EP | disclosed |
| US-11130745-B2 | 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH | BAYER AKTIENGELLSCHAFT (DE) | 2021-09-28 | — | — | US | disclosed |
| US-20210188805-A9 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AKTIENGESELLSCHAFT (DE) | 2021-06-24 | — | — | US | disclosed |
| US-20200377472-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AKTIENGESELLSCHAFT (DE) | 2020-12-03 | — | — | US | disclosed |
| US-10815215-B2 | 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH | BAYER AKTIENGESELLSCHAFT (DE) | 2020-10-27 | — | — | US | disclosed |
| US-20200123129-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AKTIENGESELLSCHAFT (DE) | 2020-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11713304-B2 | 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH | DHODH, DHPS, DPYD | SORT1 4845/4885NOTUM 956/4885CHRM2 3910/4885 |
| US-11130745-B2 | 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH | DHODH, DPYD, DHPS | SORT1 4847/4885NOTUM 1132/4885CHRM2 3875/4885 |
| US-20200123129-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | DHODH, DPYD, DHPS | SORT1 4847/4885NOTUM 1132/4885CHRM2 3875/4885 |
| US-20210188805-A9 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | DHODH, DPYD, DHPS | SORT1 4847/4885NOTUM 1132/4885CHRM2 3875/4885 |
| US-20200377472-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | DHODH, DPYD, DHPS | SORT1 4847/4885NOTUM 1132/4885CHRM2 3875/4885 |
| US-20220135536-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | DHODH, DHPS, DPYD | SORT1 4845/4885NOTUM 956/4885CHRM2 3910/4885 |
| US-10815215-B2 | 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH | DHODH, DPYD, DHPS | SORT1 4847/4885NOTUM 1132/4885CHRM2 3875/4885 |
| US-20230365524-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | DHODH, DHPS, DPYD | SORT1 4845/4885NOTUM 956/4885CHRM2 3910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.