Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15435923 | 0.84 | NAMPT (0.43) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| SCHEMBL31305375 | 0.83 | ALOX15 (0.50) | ALDH1A1KDM4EALOX15 | |
| SCHEMBL25064684 | 0.83 | MAPK1 (0.42) | SIGMAR1ALDH1A1LMNAGAAMAPT | |
| SCHEMBL16758742 | 0.83 | HSD11B1 (0.47) | ALDH1A1KCNA5KDM4ETDP1MEN1 | |
| SCHEMBL20745447 | 0.83 | HSD11B1 (0.47) | ALDH1A1KCNA5KDM4ETDP1MEN1 | |
| SCHEMBL3553321 | 0.82 | NAMPT (0.44) | ALDH1A1MAPK1KCNA5PARP1TEAD3 | |
| SCHEMBL15435928 | 0.81 | MEN1 (0.51) | SIGMAR1ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL30958401 | 0.81 | ALOX15 (0.52) | ALOX15 | |
| SCHEMBL6644497 | 0.80 | SIGMAR1 (0.49) | SIGMAR1ALOX15 | |
| SCHEMBL7604063 | 0.79 | TACR1 (0.40) | SIGMAR1KCNA5TEAD3LTA4HTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081682-A1 | DEGRADERS OF WILD-TYPE AND MUTANT FORMS OF LRRK2 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |