Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCUN1D1 | Q96GG9 | 9/20 | 0.49 |
| ▸ | UBE2M | P61081 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | IDH2 | P48735 | 1/20 | 0.46 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.45 |
| ▸ | MLNR | O43193 | 2/20 | 0.45 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11577402 | 0.82 | UBE2M (0.63) | DCUN1D1UBE2MMEN1KMT2AROCK2 | |
| SCHEMBL21856330 | 0.82 | ROCK2 (0.52) | DCUN1D1UBE2MMEN1KMT2AROCK2 | |
| SCHEMBL21959807 | 0.80 | IDH2 (0.47) | DCUN1D1UBE2MMEN1KMT2AIDH2 | |
| SCHEMBL24781281 | 0.78 | IDH2 (0.62) | DCUN1D1UBE2MMEN1KMT2AIDH2 | |
| SCHEMBL4750850 | 0.77 | DRD2 (0.63) | DCUN1D1UBE2MMEN1KMT2AIDH2 | |
| SCHEMBL21856323 | 0.77 | IDH2 (0.45) | DCUN1D1UBE2MMEN1KMT2AIDH2 | |
| SCHEMBL24781034 | 0.75 | IDH2 (0.50) | DCUN1D1UBE2MMEN1KMT2AROCK2 | |
| SCHEMBL21959809 | 0.75 | EPHX2 (0.50) | MEN1KMT2AROCK2IDH2TEAD1 | |
| SCHEMBL21856317 | 0.75 | IDH2 (0.43) | DCUN1D1UBE2MMEN1KMT2AIDH2 | |
| SCHEMBL12969653 | 0.75 | IDH2 (0.73) | DCUN1D1UBE2MMEN1KMT2AIDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081572-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-23 | — | — | WO | disclosed |