Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 3/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.41 |
| ▸ | BCL6 | P41182 | 2/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | HCK | P08631 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.32 |
| ▸ | PRKDC | P78527 | 2/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22978515 | 0.85 | P2RX3 (0.37) | P2RX3P2RX2BCL6PDGFRBPDGFRA | |
| SCHEMBL22978636 | 0.85 | P2RX3 (0.37) | P2RX3P2RX2BCL6PDGFRBPDGFRA | |
| SCHEMBL30525606 | 0.85 | P2RX3 (0.37) | P2RX3P2RX2BCL6PDGFRBPDGFRA | |
| SCHEMBL14453800 | 0.85 | P2RX3 (0.44) | P2RX3P2RX2PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL12299816 | 0.82 | P2RX3 (0.41) | P2RX3P2RX2ALDH1A1 | |
| SCHEMBL12235180 | 0.80 | P2RX3 (0.45) | P2RX3P2RX2ALDH1A1GAA | |
| SCHEMBL14183063 | 0.78 | P2RX3 (0.40) | P2RX3P2RX2PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL1827513 | 0.77 | ALDH1A1 (0.39) | P2RX3P2RX2PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL13698778 | 0.77 | HTR2A (0.41) | KDR | |
| SCHEMBL22995089 | 0.76 | L3MBTL1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844044-B2 | WDR5 inhibitors and modulators | VANDERBILT UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |
| US-20200102288-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2020-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200102288-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | P2RX3 3502/4885P2RX2 3345/4885BCL6 711/4885 |
| US-10844044-B2 | WDR5 inhibitors and modulators | WDR5, WDR1, WDR3 | P2RX3 3487/4885P2RX2 3338/4885BCL6 719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.