Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXO1 | Q12778 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.35 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186997 | 0.91 | IRAK4 (0.41) | CSNK1ECSNK1DIRAK4NPC1RAB9A | |
| SCHEMBL2187178 | 0.88 | CSNK1D (0.45) | CSNK1ECSNK1DMPLNPC1RAB9A | |
| SCHEMBL2187052 | 0.87 | NPC1 (0.50) | CSNK1ECSNK1DNPC1RAB9ATP53 | |
| SCHEMBL2189024 | 0.84 | CSNK1E (0.49) | CSNK1ECSNK1DNPC1TP53SMN1; SMN2 | |
| SCHEMBL2187598 | 0.84 | FOXO1 (0.40) | FOXO1CSNK1ECSNK1DIRAK4NPC1 | |
| SCHEMBL2186979 | 0.83 | MAPT (0.44) | CSNK1ENPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL2186693 | 0.83 | MMP2 (0.46) | NPC1RAB9ATP53SMN1; SMN2KDM4E | |
| SCHEMBL2186596 | 0.83 | CSNK1E (0.47) | CSNK1ECSNK1DIRAK4NPC1RAB9A | |
| SCHEMBL2189072 | 0.79 | CSNK1E (0.58) | CSNK1ECSNK1DNPC1RAB9ATP53 | |
| SCHEMBL2187182 | 0.76 | CSNK1E (0.47) | CSNK1ECSNK1DNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |