Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187052 | 0.87 | NPC1 (0.50) | MAPTPOLBALDH1A1KDM4EHTT | |
| SCHEMBL2186997 | 0.87 | IRAK4 (0.41) | MEN1KMT2AKDM4ENPSR1TDP1 | |
| SCHEMBL2187178 | 0.84 | CSNK1D (0.45) | KDM4ENPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL2186693 | 0.84 | MMP2 (0.46) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2189024 | 0.83 | CSNK1E (0.49) | NPSR1NPC1SMN1; SMN2LMNATP53 | |
| SCHEMBL2186602 | 0.83 | FOXO1 (0.40) | KDM4ENPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL2187310 | 0.81 | NPC1 (0.52) | MAPTPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL2189072 | 0.81 | CSNK1E (0.58) | SLC40A1NPC1RAB9ALMNATP53 | |
| SCHEMBL2186970 | 0.80 | NPC1 (0.49) | MAPTPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL2185628 | 0.79 | SMN1; SMN2 (0.39) | MAPTPOLBCYP1A2NPSR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |