Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 3/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.44 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2189072 | 0.90 | CSNK1E (0.58) | CSNK1ECSNK1DCSNK1G3SLC40A1MTOR | |
| SCHEMBL2186882 | 0.83 | CSNK1E (0.65) | CSNK1ECSNK1DCSNK1G3SLC40A1MEN1 | |
| SCHEMBL2187181 | 0.82 | CSNK1E (0.56) | CSNK1ECSNK1DCSNK1G3SLC40A1MEN1 | |
| SCHEMBL2187310 | 0.81 | NPC1 (0.52) | CSNK1ECSNK1DCSNK1G3MEN1KMT2A | |
| SCHEMBL2187178 | 0.80 | CSNK1D (0.45) | CSNK1ECSNK1DKDM4ESMN1; SMN2MTOR | |
| SCHEMBL2187052 | 0.80 | NPC1 (0.50) | CSNK1ECSNK1DKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL2186979 | 0.78 | MAPT (0.44) | CSNK1ESLC40A1MEN1KMT2AKDM4E | |
| SCHEMBL2186693 | 0.76 | MMP2 (0.46) | MEN1KMT2AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL2186602 | 0.76 | FOXO1 (0.40) | CSNK1ECSNK1DKDM4ESMN1; SMN2MTOR | |
| SCHEMBL2189024 | 0.76 | CSNK1E (0.49) | CSNK1ECSNK1DCSNK1G3SMN1; SMN2MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |