SCHEMBL218666

SCHEMBL218666

CC(=O)n1c(N)nc2[nH]cnc2c1=O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GDA Q9Y2T3 2/20 0.34
PDE4A P27815 4/20 0.32
PDE4B Q07343 4/20 0.32
PDE4C Q08493 4/20 0.32
PDE4D Q08499 4/20 0.32
PNP P00491 1/20 0.31
ATAD2 Q6PL18 1/20 0.31
MGMT P16455 1/20 0.31
LMNA P02545 1/20 0.31
CYP1A2 P05177 1/20 0.31
MAPT P10636 1/20 0.31
ADORA2A P29274 2/20 0.30
ADORA2B P29275 2/20 0.30
PIK3CD O00329 1/20 0.30
ALPL P05186 1/20 0.30
ADORA3 P0DMS8 1/20 0.30
TMIGD3 P0DMS9 1/20 0.30
ADORA1 P30542 1/20 0.30
CYP2C19 P33261 1/20 0.30
HIF1A Q16665 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL8165610 0.98 GDA (0.33) GDAPDE4APDE4BPDE4CPDE4D
SCHEMBL453202 0.84 GDA (0.32) GDAADORA2AADORA2B
SCHEMBL8843867 0.82 PDE4A (0.38) PDE4APDE4BPDE4CPDE4DCYP1A2
SCHEMBL2940012 0.82 KDM4E (0.46) GDAPNPPARP1
SCHEMBL3072977 0.81 MGMT (0.32) PDE4APDE4BPDE4CPDE4DMGMT
SCHEMBL5694185 0.79 NPC1 (0.51) PNPLMNACYP1A2MAPT
SCHEMBL5347861 0.78 XDH (0.42) PDE4APDE4BPDE4CPDE4DLMNA
SCHEMBL2983845 0.78 PNP (0.34) GDAPDE4APDE4BPDE4CPDE4D
SCHEMBL20866 0.78 ATAD2 (0.41) PDE4APDE4BPDE4CPDE4DPNP
SCHEMBL1740456 0.76 ALDH1A1 (0.36) PDE4APDE4BPDE4CPDE4DPNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114047262-B Method for separating and measuring easily-hydrolyzed large polar compound 湖北省宏源药业科技股份有限公司 2024-12-13 CN claimed
CN-114047262-A Method for separating and measuring easily hydrolyzed large-polarity compound 湖北省宏源药业科技股份有限公司 2022-02-15 CN claimed
CN-113735857-A Acyclovir potential impurity and preparation method thereof 湖北省宏源药业科技股份有限公司 2021-12-03 CN claimed
WO-2006102970-A9 MODIFIED SHORT INTERFERING RNA QIAGEN GMBH (DE) 2016-05-26 WO claimed
US-8088752-B2 Methods for metabolic modulation VDF FUTURECEUTICALS, INC. (US) 2012-01-03 US claimed
EP-2157182-A2 Modified short interfering RNA Qiagen GmbH (DE) 2010-02-24 EP claimed
US-20090197332-A1 Modified Short Interfering RNA QIAGEN GMBH (DE) 2009-08-06 US claimed
EP-1863912-A2 MODIFIED SHORT INTERFERING RNA Qiagen GmbH (DE) 2007-12-12 EP claimed
US-20070184067-A1 Alimentary compositions and methods for metabolic modulation VDF FUTURECEUTICALS 2007-08-09 US claimed
WO-2006102970-A2 MODIFIED SHORT INTERFERING RNA QIAGEN GMBH (DE) 2006-10-05 WO claimed
EP-0747389-B1 3'-SUBSTITUTED NUCLEOSIDE DERIVATIVES TAIHO PHARMACEUTICAL CO LTD (JP) 2003-09-10 EP claimed
WO-2003033498-A2 A PROCESS FOR THE TREATMENT OF GANCICLOVIR INTERMEDIATE N2-ACETYL-9-(1, 3-DIACETOXY-2-PROPOXYMETHYL) GUANINE RANBAXY LABORATORIES LIMITED (IN) 2003-04-24 WO claimed
US-RE38090-E1 Antitumor activity; useful for treatment and prevention of cancers Matsuda, Akira (JP) 2003-04-22 US claimed
EP-0763047-B1 NOVEL METHOD OF PRODUCING NUCLEOSIDES HOECHST AG (DE) 2002-01-23 EP claimed
WO-1997014709-A1 ANTISENSE OLIGOMERS F. HOFFMANN-LA ROCHE AG (CH) 1997-04-24 WO claimed
WO-1997011944-A1 IMPROVED PROCESS FOR PRODUCING 9-(2-HYDROXYETHOXY)-METHYLGUANINE (ACYCLOVIR) BOEHRINGER INGELHEIM KG (DE) 1997-04-03 WO claimed
EP-0747389-A1 3'-SUBSTITUTED NUCLEOSIDE DERIVATIVES TAIHO PHARMACEUTICAL CO., LTD. (JP) 1996-12-11 EP claimed
EP-0243670-B1 PURINE AND PYRIMIDINE COMPOUNDS AND THEIR USE AS ANTI-VIRAL AGENTS SYNTEX (U.S.A.) INC. (US) 1992-07-22 EP claimed
WO-1992011276-A1 NOVEL SYNTHESIS OF 2'-'UP' FLUORINATED 2''-DEOXY-ARABINOFURANOSYLPURINES SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1992-07-09 WO claimed
EP-0243670-A1 Purine and pyrimidine compounds and their use as anti-viral agents SYNTEX (U.S.A.) INC. (US) 1987-11-04 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090197332-A1 Modified Short Interfering RNA NSUN2, NSUN3, METTL16 GDA 1238/4885PDE4A 3647/4885PDE4B 3552/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.