Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | PRNP | P04156 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1124226 | 0.91 | DHODH (0.78) | DHODHALDH1A1HPGDKDM4EGAA | |
| SCHEMBL2186276 | 0.86 | DHODH (0.82) | DHODHALDH1A1HPGDKDM4ECYP3A4 | |
| SCHEMBL2186832 | 0.85 | RAB9A (0.58) | DHODHALDH1A1HPGDKDM4EGAA | |
| SCHEMBL2211815 | 0.80 | KMT2A (0.58) | GAARXFP1MEN1KMT2ALMNA | |
| SCHEMBL1703428 | 0.79 | DHODH (0.51) | DHODHHPGDGAAPKMRXFP1 | |
| SCHEMBL1389175 | 0.79 | PKM (0.74) | ALDH1A1HPGDPKMPPARGNCOR2 | |
| SCHEMBL3640599 | 0.79 | DHODH (0.51) | DHODHALDH1A1HPGDKDM4EGAA | |
| SCHEMBL1704235 | 0.78 | LMNA (0.54) | DHODHHPGDKDM4EPKMRXFP1 | |
| SCHEMBL11596321 | 0.78 | RXFP1 (0.72) | DHODHALDH1A1HPGDGAAPKM | |
| SCHEMBL1810535 | 0.78 | DHODH (1.00) | DHODHALDH1A1HPGDKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578741-B1 | AROMATIC COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS | 4SC AG (DE) | 2011-07-13 | — | — | EP | claimed |
| EP-1578741-B1 | AROMATIC COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |