Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186594 | 0.82 | TNKS (0.49) | TSHRTNKSPARP1PARP10TNKS2 | |
| SCHEMBL2187921 | 0.82 | SMN1; SMN2 (0.52) | TSHRMAPTSMN1; SMN2HTTNPSR1 | |
| SCHEMBL2185907 | 0.81 | TSHR (0.51) | TSHRMAPTSMN1; SMN2HTTNPSR1 | |
| SCHEMBL2187763 | 0.81 | TSHR (0.51) | TSHRMAPTSMN1; SMN2HTTNPSR1 | |
| SCHEMBL2187684 | 0.80 | HSD11B1 (0.48) | TNKSPARP1PARP10TNKS2KDM4E | |
| SCHEMBL2186442 | 0.79 | LMNA (0.58) | TSHRMAPTSMN1; SMN2HTTHSD17B10 | |
| SCHEMBL2188250 | 0.78 | LMNA (0.51) | TSHRMAPTHTTNPSR1HSD17B10 | |
| SCHEMBL2187717 | 0.78 | LMNA (0.53) | TSHRMAPTSMN1; SMN2HTTNPSR1 | |
| SCHEMBL2187509 | 0.78 | LMNA (0.57) | TSHRMAPTSMN1; SMN2HTTHSD17B10 | |
| SCHEMBL2192226 | 0.77 | KMT2A (0.55) | TSHRMAPTSMN1; SMN2HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |
| EP-1637529-A1 | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof | 4SC AG (DE) | 2006-03-22 | — | — | EP | disclosed |