Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | TNKS | O95271 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.48 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.42 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186594 | 0.85 | TNKS (0.49) | TNKSPARP1PARP10TNKS2TRPC3 | |
| SCHEMBL2186835 | 0.80 | TSHR (0.46) | TNKSPARP1PARP10TNKS2TRPC3 | |
| SCHEMBL2188126 | 0.77 | ALDH1A1 (0.50) | HSD11B1KDM4EBRD4ALDH1A1POLB | |
| SCHEMBL2213735 | 0.76 | KDM4E (0.52) | HSD11B1KDM4EBRD4ALDH1A1POLB | |
| SCHEMBL2186733 | 0.76 | KDM4E (0.48) | HSD11B1KDM4EBRD4ALDH1A1POLB | |
| SCHEMBL2188470 | 0.73 | KDM4E (0.51) | HSD11B1KDM4EBRD4ALDH1A1POLB | |
| SCHEMBL5774732 | 0.72 | KDM4E (0.43) | HSD11B1KDM4EBRD4ALDH1A1POLB | |
| SCHEMBL2187334 | 0.71 | KDM4E (0.39) | HSD11B1KDM4EBRD4ALDH1A1POLB | |
| SCHEMBL2187329 | 0.71 | SLC6A4 (0.45) | SLC6A4KDM4EBRD4ALDH1A1POLB | |
| SCHEMBL2186025 | 0.70 | KDM4E (0.46) | DRD2HTR2AKDM4EBRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |
| EP-1637529-A1 | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof | 4SC AG (DE) | 2006-03-22 | — | — | EP | disclosed |