Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 10/20 | 0.48 |
| ▸ | CA2 | P00918 | 10/20 | 0.48 |
| ▸ | CA9 | Q16790 | 9/20 | 0.48 |
| ▸ | CA12 | O43570 | 6/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927055 | 0.73 | KDM4E (0.43) | KDM4EGLAMAPTKMT2AKDM1A | |
| SCHEMBL5064901 | 0.72 | DHFR (0.50) | CA1CA2CA9CA12CA7 | |
| Diphenylether SCHEMBL28109377 | 0.67 | CA1 (0.71) | CA1CA2CA9CA12CA7 | |
| SCHEMBL16463309 | 0.66 | ADORA2A (0.49) | NUDT1DCPSNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16516258 | 0.66 | LTA4H (0.53) | — | |
| SCHEMBL13195034 | 0.65 | POLB (0.45) | KDM4EGLAMAPTKMT2AKDM1A | |
| SCHEMBL16828235 | 0.64 | ADORA2A (0.55) | CA1CA2CA9CA12KDM4E | |
| Diphenylether SCHEMBL27837900 | 0.64 | SOS1 (0.88) | CA1CA2CA9CA12CA7 | |
| SCHEMBL9178404 | 0.64 | SMN1; SMN2 (0.52) | CA1CA2CA9KDM4EGLA | |
| SCHEMBL15648269 | 0.64 | CA2 (1.00) | CA1CA2CA9CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9643934-B2 | Process for synthesis of phenoxy diaminopyrimidine derivatives | ROCHE PALO ALTO LLC (US) | 2017-05-09 | — | — | US | disclosed |
| EP-2079713-B1 | PROCESS FOR SYNTHESIS OF PHENOXY DIAMINOPYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-04-16 | — | — | EP | disclosed |
| EP-2343281-B1 | Process for synthesis of phenoxy diaminopyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 2014-03-05 | — | — | EP | disclosed |
| US-20140045871-A1 | PROCESS FOR SYNTHESIS OF PHENOXY DIAMINOPYRIMIDINE DERIVATIVES | ROCHE PALO ALTO LLC (US) | 2014-02-13 | — | — | US | disclosed |
| US-8580960-B2 | Process for synthesis of phenoxy diaminopyrimidine derivatives | ROCHE PALO ALTO LLC (US) | 2013-11-12 | — | — | US | disclosed |
| CN-101522641-B | Method for synthesizing phenoxyl diaminopyrimidine derivatives | HOFFMANN LA ROCHE | 2012-07-04 | — | — | CN | disclosed |
| CN-102432548-A | Process for synthesis of phenoxy diaminopyrimidine derivatives | ROCHE PALO ALTO LLC | 2012-05-02 | — | — | CN | disclosed |
| US-20110269961-A1 | PROCESS FOR SYNTHESIS OF PHENOXY DIAMINOPYRIMIDINE DERIVATIVES | ROCHE PALO ALTO LLC. | 2011-11-03 | — | — | US | disclosed |
| US-8003788-B2 | To a cooled solution of ammonia was added the cooled sulfolane solution of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonyl chloride to form -(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide sulfolane solvate | ROCHE PALO ALTO LLC (US) | 2011-08-23 | — | — | US | disclosed |
| EP-2343281-A1 | Process for synthesis of phenoxy diaminopyrimidine derivatives | F. Hoffmann-La Roche AG (CH) | 2011-07-13 | — | — | EP | disclosed |
| CN-101522641-A | Method for synthesizing phenoxyl diaminopyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 2009-09-02 | — | — | CN | disclosed |
| US-20080086004-A1 | Process for synthesis of phenoxy diaminopyrimidine derivatives | ROCHE PALO ALTO LLC | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080086004-A1 | Process for synthesis of phenoxy diaminopyrimidine derivatives | DPYD, PDXK, PKN2 | CA1 3469/4885CA2 2186/4885CA9 1767/4885 |
| US-20110269961-A1 | PROCESS FOR SYNTHESIS OF PHENOXY DIAMINOPYRIMIDINE DERIVATIVES | DPYD, PDXK, PKN2 | CA1 3469/4885CA2 2186/4885CA9 1767/4885 |
| US-20140045871-A1 | PROCESS FOR SYNTHESIS OF PHENOXY DIAMINOPYRIMIDINE DERIVATIVES | DPYD, PDXK, PKN2 | CA1 3469/4885CA2 2186/4885CA9 1767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.