Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 3/20 | 0.35 |
| ▸ | ATF4 | P18848 | 4/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23920087 | 0.86 | AHR (0.35) | AHRHTR2CCHRNB2CHRNA4CHEK1 | |
| SCHEMBL21882007 | 0.79 | AKR1B1 (0.39) | ADAMTS5AHRNISCHCYP1A2CYP3A4 | |
| SCHEMBL21621076 | 0.79 | AHR (0.39) | ADAMTS5AHRATF4NISCHKMT2A | |
| SCHEMBL21882006 | 0.79 | AKR1B1 (0.39) | ADAMTS5AHRNISCHCYP1A2CYP3A4 | |
| SCHEMBL23920549 | 0.79 | AHR (0.39) | ADAMTS5AHRATF4NISCHKMT2A | |
| SCHEMBL21882013 | 0.79 | AKR1B1 (0.39) | ADAMTS5AHRNISCHCYP1A2CYP3A4 | |
| SCHEMBL24997269 | 0.76 | GBA1 (0.39) | ADAMTS5HTR2C | |
| SCHEMBL24997327 | 0.76 | CA2 (0.40) | ADAMTS5ATF4HTR2C | |
| SCHEMBL22397074 | 0.76 | ADAMTS5 (0.40) | ADAMTS5ATF4CHEK1 | |
| SCHEMBL22397099 | 0.76 | ADAMTS5 (0.40) | ADAMTS5ATF4CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11166942-B2 | Inhibitors of integrated stress response pathway | Praxis Biotech LLC (US) | 2021-11-09 | — | — | US | disclosed |
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. | 2021-10-14 | — | — | US | disclosed |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2020-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | ADAMTS5 4307/4885AHR 3302/4885ATF4 1/4885 |
| US-11166942-B2 | Inhibitors of integrated stress response pathway | ATF4, DDIT3, ATF1 | ADAMTS5 4307/4885AHR 3302/4885ATF4 1/4885 |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | ADAMTS5 4307/4885AHR 3302/4885ATF4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.