Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | ATF4 | P18848 | 3/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21621076 | 1.00 | AHR (0.39) | AHRADAMTS5HTR2CKDM4EMEN1 | |
| SCHEMBL21882007 | 0.79 | AKR1B1 (0.39) | AHRADAMTS5HTR2CMAPTKMT2A | |
| SCHEMBL21882006 | 0.79 | AKR1B1 (0.39) | AHRADAMTS5HTR2CMAPTKMT2A | |
| SCHEMBL21882009 | 0.79 | ADAMTS5 (0.38) | AHRADAMTS5HTR2CKMT2AATF4 | |
| SCHEMBL21882013 | 0.79 | AKR1B1 (0.39) | AHRADAMTS5HTR2CMAPTKMT2A | |
| SCHEMBL24997327 | 0.79 | CA2 (0.40) | ADAMTS5HTR2CCA2CA1ATF4 | |
| SCHEMBL30052791 | 0.79 | CA2 (0.40) | ADAMTS5HTR2CCA2CA1ATF4 | |
| SCHEMBL24997390 | 0.78 | ADAMTS5 (0.49) | ADAMTS5KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL30054581 | 0.78 | ADAMTS5 (0.49) | ADAMTS5KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24997269 | 0.76 | GBA1 (0.39) | ADAMTS5HTR2CCA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | AHR 3302/4885ADAMTS5 4307/4885HTR2C 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.